Advanced Equipment
The The Maurice and Vivienne Wohl Institute for Drug Discovery unit offers a collection of industry-standard instruments to enable miniaturization and automation of most biological assay systems.
Many of these devices can be operated in stand-alone or in integrated automation platforms to allow runs of several plates to hundreds of plates.
Advanced Equipment MedicinalChemistry
Our organic chemistry lab is outfitted with state of the art equipment to support synthesis of most compounds of biological interest.
Instrumentation includes the following:
Microwave reactor: Biotage Initiator +
Biotage® Initiator+ represents the latest in microwave synthesis performance. This instrument’s high-end specifications enable the chemist to explore new areas and perform the latest of innovations in chemistry. A reliable and upgradeable platform that allows chemists to make great discoveries in less time.
UPLC MS: WATERS Acquity H Class UPLC with SQD2, PDA, and ELSD detectors
Improve your laboratory’s efficiency by scaling your methods to UPLC Technology
Use UPLC’s unmatched resolution to get better characterization of your complex samples
Take advantage of tools that simplify and streamline your method development workflow
Future-proof your lab by running your existing HPLC and UHPLC methods today and then transitioning to UPLC when you are ready.
Speed Vac: CentriVap Concentrator , LABCONCO
CentriVap Benchtop Vacuum Concentrators are designed to rapidly concentrate multiple small samples using centrifugal force, vacuum and heat. As many as 132 samples may be processed at once. Sample sizes range from a few microliters up to 25 milliliters. CentriVap Concentrators are also available as one component of CentriVap Concentration Systems.
Flow Hydrogenation: Thales Nano H-Cube Pro
The H-Cube Pro™ is the next generation version of the number one selling flow reactor, the H-Cube®. The H-Cube Pro™ takes the best of the H-Cube®, such as fast reactions, safe high pressure hydrogen generation from water, catalyst cartridges, and ease of use, and improves upon it dramatically.
Agilent 1260 Bio-Inert
This uHPLC includes photodiode array and cooled fraction collector. We use it for fractionating peptides in deep proteomics experiments and for enrichment of phosphopeptides.
Rotavapor R-300
Comfortable flask and vapor duct removal thanks to easy to use Combi-Clip User-friendly operation due to ergonomic electric or manual lift
Immediate adjustment of heating temperature and rotation speed with intuitively positioned control knobs.
CombiFlash® EZ Prep System
The CombiFlash® EZ Prep offers streamlined Flash and Prep HPLC chromatography in one compact, easy-to-operate unit. With just two clicks, users can switch from pre-purifying samples on Flash to generating submission-quality compounds on Prep ?HPLC. Teledyne Isco's RFID-encoded collection racks ensure proper loading every time and allows users to hot-swap racks during separation for virtually limitless fraction collection capability.?
The EZ Prep also comes equipped with Teledyne Isco's PeakTrak® software, a comprehensive package which integrates all detector options for single-point control. Designed with simplicity and ease-of-use in mind, PeakTrak allows even the most novice users to begin purifying samples within minutes.
nanoUPLC+Q Exactive Plus
The platform includes state-of-the-art ultra performance liquid chromatography coupled with high-resolution tandem mass spectrometry. It is used for unbiased identification and quantification of peptides and proteins as well as targeted analysis in parallel reaction monitoring (PRM).
TIMS-ToF Ultra
The new timsTOF Ultra is our newest instrument, the most sensitive mass spectrometer for proteomics analysis, to date. It combines the power of Ion Mobility and PASEF technology and will facilitate single cell proteomics in the near future.
Liberty Blue Synthesizer
The Liberty Blue Automated Microwave Peptide Synthesizer is the gold standard for peptide
synthesis. It features 4-minute cycle times along with a 90% solvent reduction based on High Eficiency Solid Phase Peptide Synthesis (HE-SPPS).
Modes of access
1. Staff-assisted access is free of charge following training by INCPM
2. Full-service production of peptides by the Medicinal Chemistry unit
https://g-incpm.weizmann.ac.il/eform/submit/project
Contact: khiresto.shurrush@weizmann.ac.il
Mantis Liquid Handler Formulatrix
The MANTIS® Liquid Handler provides a novel approach to reagent dispensing.
The Mantis is a programmable, low volume, low dead-volume, non-contact liquid dispenser that can reliably dispense a variety of solutions including those containing beads, cells, proteins, enzymes, nucleic acids and highly concentrated salts.
The MANTIS dispenses any reagent efficiently and reproducibly regardless of volume, viscosity, temperature, concentration, time of day, and research experience.
Waters mass-triggered HPLC e2695
The mass triggered HPLC is used for rapid purification of small molecules with mass ranging from 300-1000Da. This instrument is primarily used for milligram scale production of small organic compounds
HTS 1 (large scale screening system)
This system includes:
- Thermo Spinnaker Robot
- BMG Pherastar FS plate reader
- Agilent Bravo liquid handler
- Biotek EL406 plate washer
- BNX 1536 plate washer
- Thermo Combi dispenser (2 units)
- Thermo C10 hotel (250 plate ambient storage)
- Liconic STX 220 (220 plate incubation)
- Bluecatbio Blue washer
- CertusFlex dispenser
TIMS-ToF Pro
The TIMS ToF Pro mass spectrometer is among the most sensitive and sophisticated instruments currently available. The core technology is quadrupole time of light and it also includes an ion mobility chamber for an additional separation dimension.
New: Nanostring nCounter analysis system flex
The nCounter® platform provides a simple and cost-effective solution of direct digital quantification for multiplex analysis of up to 800 known RNA, DNA, or protein targets in one tube.
NanoString’s nCounter technology uses color-coded molecular barcodes that can hybridize directly to many different types of target molecules. It is ideal for a range of applications requiring efficient, high-precision quantitation of hundreds of target molecules across a sample set.
Portable Modular Data Center
Portable Modular Data Center (PMDC) 'All in one' solution provides a fully functional Data Center inside a regular ISO 40” High Cube container with complete infrastructure including: cooling, power, structural protection, fire protection, monitoring, access control, etc., achieving a total plug and play solution within a secure environment design, comprising a modular and flexible approach at the lowest PUE.
Key Features:
- Time wise: expected to take four months from start.
- Allocated space: 14 Racks Net.
- Power consumption: capped at 100 – 150 kW for the facility.
- UPS: 2 Units of 100KVA N+2 redundancy.
- Generator: 300 KVA with 10 Hours Fuel.
- Climate Control: N+1 Configuration.
- Fire extinguishing system.
- Remote Monitoring and alarm system
Illumina NovaSeq X Plus
The newest high throughput Illumina sequencing platform NovaSeq X Plus. It presents XLEAP-SBS chemistry that delivers the highest level of data accuracy and performance, with increased stability.
NextSeq500
The NextSeq500 desktop sequencing system enables faster sequencing (~5.5 min/cycle) which enables it to perform the 150 PE sequencing run in less than 30hrs. Combine with a greater yield than the hiseq machine (400M reads per run), it is suitable for most of the sequencing applications and is less ideal for low complexity libraries.
nanoUPLC + Exploris 480 + FAIMS
The Thermo Scientific Orbitrap Exploris 480 provides better acucracy and deeper examination of samples, and thus maximizes high-throughput performance in proteomics and biopharma applications.
* This equipment has been generously provided by USAID from the American People.
IBM Flex System
IBM Flex System, a new category of computing and the next generation of Smarter Computing, is anchored by the IBM Flex System Enterprise Chassis. This platform offers intelligent workload deployment and management for maximum business agility. This chassis delivers high-speed performance complete with integrated servers, storage, and networking for multi-chassis management in datacenter compute environments. Furthermore, its flexible design can meet the needs of varying workloads with independently scalable IT resource pools for higher utilization and lower cost per workload. While increased security and resiliency protect vital information and promote maximum uptime, the integrated, easy-to-use management system reduces setup time and complexity, providing a quicker path to ROI.
MiSeq
The MiSeq desktop sequencer enables a broad range of applications, such as targeted gene sequencing, metagenomics, small genome sequencing, targeted gene expression, amplicon sequencing, and HLA typing. MiSeq is the only desktop sequencer that can produce 2 x 300 paired-end reads in a single run.
Orbitrap Fusion Lumos with ETD
This is the most advanced mass spectrometer used for protein and peptide analysis. It houses several technologies in one box. Its unique features help us to localise post translational modifications and identify glycopeptides.
Cisco UCS B200
The Cisco UCS B200 M5 Blade Server delivers performance, flexibility, and optimization for deployments in data centers, in the cloud, and at remote sites. This enterprise-class server offers market-leading performance, versatility, and density without compromise for workloads including Virtual Desktop Infrastructure (VDI), web infrastructure, distributed databases, converged infrastructure, and enterprise applications such as Oracle and SAP HANA. The B200 M5 server can quickly deploy stateless physical and virtual workloads through programmable, easy-to-use Cisco UCS Manager Software and simplified server access through Cisco SingleConnect technology.
HCS (automated microscopy and imaging)
This system includes:
- HiRes Acell robot arm
- Molecular Devices ImagExpress confocal microscop
- TTPlabtech Acumen scanning cytometer
- Liconic STX 44 (44 plate incubation)
- IncuCyte - real-time live cell imaging and analysis
10X Genomics, Chromium iX
The new GEM-X technology creates a unique reagent delivery system that partitions cells or nuclei and prepares sequencing libraries in parallel such that all fragments produced within a partition share a common barcode.
IBM Spectrum Scale™
IBM Spectrum Scale™ is a cluster file system that provides concurrent access to a single file system or set of file systems from multiple nodes. The nodes can be SAN attached, network attached, a mixture of SAN attached and network attached, or in a shared nothing cluster configuration. This enables high performance access to this common set of data to support a scale-out solution or to provide a high availability platform.
IBM Spectrum Scale has many features beyond common data access including data replication, policy based storage management, and multi-site operations. You can create a cluster of AIX® nodes, Linux nodes, Windows server nodes, or a mix of all three. IBM Spectrum Scale can run on virtualized instances providing common data access in environments, leverage logical partitioning, or other hypervisors. Multiple IBM Spectrum Scale clusters can share data within a location or across wide area network (WAN) connections.
CM 1 (assay plate preparation)
This system includes:
- Labcyte Access robot arm
- Labcyte Echo 555 acoustic liquid handler; 2 units
- Thermo Cytomat C24 (500 plates incubator)
- Thermo Cytomat 6002 (250 plates dry storage)
- Agilent Vspin plate centrifuge
- Agilent Plateloc plate sealer
- Brooks Xpeel plate peeler
nanoUPLC + Q Exactive HF-X
This instrument is used primarily for whole proteome analysis and global post-translational modifications. It is among our most sensitive instruments.
nanoUPLC+Q Exactive HF
The platform includes state-of-the-art ultra performance liquid chromatography coupled with high-resolution tandem mass spectrometry. It is used for unbiased identification and quantification of peptides and proteins as well as targeted analysis in parallel reaction monitoring (PRM).
IBM XIV®
IBM XIV® is a high-end, grid-scale storage system that excels in tuning-free consistent performance, extreme ease of use, and exceptional data economics including inline, field-proven IBM Real-time Compression™. It is ideal for hybrid cloud, offering predictable service levels for dynamic workloads, simplified scale management including in multi-tenant environments, flexible consumption models — and robust cloud automation and orchestration through OpenStack, RESTful API, and VMware. It offers security and data protection through hot encryption, advanced mirroring and self-healing, and provides investment protection with perpetual licensing that is unattached to a specific XIV system. Industry benchmarks underscore stellar XIV performance and cost benefits
CM 2 (library plate management)
This system includes:
- HiRes Acell robot arm
- Agilent Bravo liquid handler
- HiRes centrifuge
- Agilent Plateloc plate sealer
- Agilent Vcode barcode printer
- HiRes nanoserve (labware storage)
- HiRes picoserve (48 plate storage)
Nanostring nCounter analysis system flex
The nCounter® platform provides a simple and cost-effective solution of direct digital quantification for multiplex analysis of up to 800 known RNA, DNA, or protein targets in one tube.
NanoString’s nCounter technology uses color-coded molecular barcodes that can hybridize directly to many different types of target molecules. It is ideal for a range of applications requiring efficient, high-precision quantitation of hundreds of target molecules across a sample set.
nanoUPLC+Q Exactive Plus
The platform includes state-of-the-art ultra performance liquid chromatography coupled with high-resolution tandem mass spectrometry. It is used for unbiased identification and quantification of peptides and proteins as well as targeted analysis in parallel reaction monitoring (PRM).
SEQUEL
PacBio SEQUEL is an award winning Single Molecule, Real-Time (SMRT) Sequencing technology.
Nanodrop Bionnex NS2
By incorporating a wide range of next-generation features into a small footprint design, Biomek NX sets the standard for flexible laboratory solutions. It puts every aspect of liquid handling – including pipetting, dilution, dispensing and integration – into a single, automated system that is as powerful as it is efficient and economical. All while offering unprecedented options for changing needs.
InfiniBox storage
The InfiniBox storage array is based on an innovative software platform built on top of industry standard hardware. InfiniBox features predictable high performance, scalability to multiple petabytes in a single 42U rack, 99.99999% uptime, and unmatched TCO for mission-critical workloads. With InfiniBox, organizations can lower both the cost and complexity of their storage operations.
- Download this data sheet to learn how the InfiniBox:
- Delivers extremely high performance
- Provides unmatched reliability
- Simplifies the most complex storage operations
- Scales to multiple petabytes
- Delivers truly unified storage
- Connects and integrates with your application ecosystem
XL 100 (compound dissolving and vial management)
This system includes:
- Biomicrolab balance
- Biomicrolab vial-handling gripper
- Tecan single channel liquid handler
Stand-alone instruments
The instruments are
- Pherastar FS Offline (plate reader)
- GNF WDII (Plate washer and dispenser)
- Thermo Combi dispenser
- Luminex (multiplex reader)
- CertusFlex Liquid dispenser
- IncuCyte - real-time live cell imaging and analysis
Agilent Bravo Automation System
Agilent Bravo Automated Liquid Handling Platform is both versatile and precise, loaded into a small, compact footprint. It is the fastest, most versatile liquid-handling system available. Providing speed and precision, Agilent’s automated liquid handling solutions cover a wide range of applications, utilizing the most advanced technologies to provide the performance and reliability that today’s scientists demand.
SGI UV 2000
Solves the Most Demanding Compute-Intensive Problems Part of the SGI UV server line for high performance in-memory computing, SGI UV 2000 is an advanced symmetric multiprocessing (SMP) system designed for compute-intensive, fast algorithm workloads such as CAE, genome assembly, and scientific simulations. SGI UV 2000 scales to truly extraordinary levels—up to 256 CPU sockets and 64TB of cache-coherent shared memory in a single system. Enabling such powerful in-memory computing capability is 6th generation SGI NUMAlink® ASIC technology, providing extreme bandwidth, low latency network interconnects. Equipped with an integrated MPI Offload Engine, UV 2000 can also be leveraged for distributed applications and as a “super node” for clustered high performance computing (HPC) systems.
H-Class Bio UPLC (Waters)
The H-Calss Bio UPLC is equipped with a fraction collector and is being used for pre fractionation of peptides and enrichment of PTMs. It is the cutting edge chromatography system, designed from the ground up for bio-compatability.
Bravo Liquid Handler
The Agilent Bravo is a flexible liquid handling platform that automates your sample preparation for screening applications such as compound management, cell-based assays, and biochemical assays. With this robotic liquid handling system, time is freed up and consistent data are achieved across samples and users.
NVIDIA virtual GPU
NVIDIA virtual GPU (vGPU) is the industry's most advanced technology for sharing the power of NVIDIA GPUs across virtual machines (VMs) and virtual applications. Amp up the power of your VDI environment and deliver a superior experience to every remote user, for every application and on any device. NVIDIA virtual GPU software products include the GRID Virtual PC (GRID vPC), GRID Virtual Apps (GRID vApps), and Quadro Virtual Data Center Workstation (Quadro vDWS). Each is designed to deliver the highest levels of performance, flexibility, manageability, and security—offering the right user experience for every virtual workflow.
Mantis Liquid Handler Formulatrix
The MANTIS® Liquid Handler provides a novel approach to reagent dispensing.
The Mantis is a programmable, low volume, low dead-volume, non-contact liquid dispenser that can reliably dispense a variety of solutions including those containing beads, cells, proteins, enzymes, nucleic acids and highly concentrated salts.
The MANTIS dispenses any reagent efficiently and reproducibly regardless of volume, viscosity, temperature, concentration, time of day, and research experience.
Actifio platform
The heart of the Actifio platform is the Virtual Data Pipeline (VDP), which virtualizes copy data, eliminating redundancies and re-purposing unique data for multiple data management applications. VDP efficiently captures a single copy or “gold copy” of data from production and reuses that data for multiple purposes, allowing applications to directly access the data from the Actifio platform without any physical data movement.
TapeStation Agilent 2200
The TapeStation Agilent 2200 system is a tape-based platform that allows DNA, RNA and protein sample QC (such as length and concentration), including sample loading, separation and imaging. The system obtains results quickly, one minute per sample and is very easy to use. DNA Screen Tape assays allow separation and analysis of genomic DNA, DNA fragments and DNA libraries. Agilent 2200 TapeStation DNA kit’s specifications are: D1000 kit for 0.1–50 ng/µL, High Sensitivity D1000 kit for 10-1000 pg/ µl and Genomic DNA kit is for 10–100 ng/µL.
Brocade 6505
The Brocade® 6505 Switch with Gen 5 Fibre Channel provides exceptional price/performance value, combining flexibility, simplicity, and enterprise-class functionality in an entry-level switch. Designed to enable maximum flexibility and reliability, the Brocade 6505 is configurable in 12 or 24 ports and supports 2, 4, 8, or 16 Gbps speeds in an efficiently designed 1U package. It comes standard with a single power supply with integrated fans. A second, optional power supply provides additional redundancy for increased resiliency. A simplified deployment process and a point-and-click user interface make the Brocade 6505 both powerful and easy to use. Moreover, the Brocade 6505 offers low-cost access to industry-leading Gen 5 Fibre Channel technology while providing “pay-as-you-grow” scalability to meet the needs of an evolving storage environment.
QuantStudio 12K Flex RT PCR
The QuantStudioTM 12K Flex Real Time PCR System facilitates real-time PCR-based applications on nanofluidic plate. With the open array technology the user can generate 1-12,000 data points in a single run. QuantStudio Digital PCR kits, Software and the OpenArray block increase the precision and sensitivity of the nucleic acid experiment by switching from qPCR to digital PCR mode.The system is fully compatible with TaqMan@ Assay formats and chemistry. Thermal blocks are easy to change (96-well, Fast 96-well, 384-well, TaqMan Array Cards and OpenArray Plates).
PCR Biometra TAdvanced
The high-performance thermal cycler for DNA amplification by PCR. Features: Fastest Ramping, Highest Accuracy and Intelligent Block/Well Control (RAC): high temperature uniformity and maximum reproducibility, no over- or undershooting of the programmed target temperature.
Cisco Nexus 5000
The Cisco Nexus 56128P is a wire-rate Layer 2 and Layer 3 switch offering 10 Gigabit Ethernet, unified ports (UP) and 2 expansion slots in a two-rack-unit form factor. It is optimized for 10 Gigabit Ethernet top-of-rack access, Cisco Fabric Extender (FEX) aggregation, VXLAN segmentation, and LAN-SAN convergence. It delivers high performance, operational efficiency, and design flexibility for traditional, virtualized, and cloud environments.
- High Scalability and Performance
- The Cisco 56128P switch is designed to meet the scaling demands of traditional and cloud deployments
- Up to 96 10GE ports (of which 48 are UP) and 8 true 40GE QSFP ports.
- Hardware based VXLAN (L2, L3, and Gateway) and NVGRE capable
- Up to 1152 ports in a single management domain via Cisco FEX architecture
- Large table sizes and buffers with 1 us latency
BluePippin
The BluePippin is a preparative electrophoresis platform that separates and collects DNA fragments using agarose gel cassettes with software-input size ranges.The BluePippin features pulse-field electrophoresis capabilities which enable accurate collection of DNA fragments in the range of 90 bp to 50 kb.The time collection of DNA fragments from samples is from 30 minutes to several hours.The BluePippin also collects targeted protein sizes from complex samples for biomarker or protein modification studies.
Covaris E220x
The E220 Focused-ultrasonicators are versatile instruments engineered for pre-analytical sample processing by Adaptive Focused Acoustics™ . Utilizing a dish-shaped acoustic transducer and computer controlled electronics; acoustic energy can be tuned to be delivered precisely and accurately to samples of varying volumes. The E220 enables multi-sample, batch preparation, capable of processing a wide range of sample types and volumes. The E220 may be programed to process from 1 to 96 samples in a single batch.