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All Publications

  • Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Shraga A., Olshvang E., Davidzohn N. et al., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T., London N. (2019), Cell Chemical Biology. 26, 1, p. 98 - 108.e5   |  All authors

  • An Efficient One-Pot Enzymatic Synthesis of Cardiac Glycosides with Varied Sugar Chain Lengths

    Huang W., Wen C., Zhou Z. et al., Fu Z., Katz A., Plotnikov A., Karlish S. J. D., Jiang R. (2019), Advanced Synthesis & Catalysis. 361, 13, p. 3114-3119   |  All authors

  • Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

    Resnick E., Bradley A., Gan J. et al., Douangamath A., Krojer T., Sethi R., Geurink P. P., Aimon A., Amitai G., Bellini D., Bennett J., Fairhead M., Fedorov O., Gabizon R., Gan J., Gu J., Plotnikov A., Reznik N., Ruda G. F., Diaz-Saez L., Straub V. M., Szommer T., Velupillai S., Zaidman D., Zhang Y., Coker A. R., Dowson C. G., Barr H. M., Wang C., Huber K. V. M., Brennan P. E., Ovaa H., von Delft F., London N. (2019), Journal of the American Chemical Society. 141, 22, p. 8951-8968   |  All authors

  • The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

    Yifa O., Weisinger K., Bassat E. et al., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brener O., Bursac N., Tzahor E. (2019), JCI insight. 4, 22, 128025   |  All authors

  • Targeting Spt5-Pol II by Small-Molecule Inhibitors Uncouples Distinct Activities and Reveals Additional Regulatory Roles

    Bahat A., Lahav O., Plotnikov A. et al., Leshkowitz D., Dikstein R. (2019), Molecular Cell. 76, 4, p. 617-631   |  All authors

  • Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

    Reznik N., Kozer N., Eisenberg-Lerner A. et al., Barr H., Merbl Y., London N. (2019), ACS Chemical Biology. 14, 12, p. 2538-2545   |  All authors

  • High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

    Yardeni T., Fine R., Joshi Y. et al., Gradus-Pery T., Kozer N., Reichenstein I., Yanowski E., Nevo S., Weiss-Tishler H., Eisenberg-Bord M., Shalit T., Plotnikov A., Barr H. M., Perlson E., Hornstein E. (2018), Scientific Reports. 8, 59   |  All authors

  • Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases

    Sapir T., Levy T., Kozer N. et al., Shin I., Zamor V., Haffner-Krausz R., McGlade J. C., Reiner O. (2018), Cerebral Cortex. 28, 9, p. 3115-3128   |  All authors

  • A multiplexed screening method for pluripotency

    Plotnikov A., Kozer N., Krupalnik V. et al., Peles S., Mor N., Rais Y., Hanna J. H., Barr H. M. (2017), Stem Cell Research. 23, p. 158-162   |  All authors

  • Effective cell-free drug screening protocol for protein-protein interaction

    Ashkenazi S., Plotnikov A., Bahat A. et al., Dikstein R. (2017), Analytical Biochemistry. 532, p. 53-59   |  All authors

  • Protein recognition by a pattern-generating fluorescent molecular probe

    Pode Z., Peri-Naor R., Georgeson J. M. et al., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L., Margulies D. (2017), Nature Nanotechnology. 12, 12, p. 1161-1168   |  All authors

  • A Novel Allosteric Mechanism of NF-kappaB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug.

    Ashkenazi S., Plotnikov A., Bahat A. et al., Ben-Zeev E., Warszawski S., Dikstein R. (2016), Molecular and Cellular Biology. 36, 8, p. 1237-47   |  All authors

  • A generic, cost-effective, and scalable cell lineage analysis platform

    Biezuner T., Spiro A., Raz O. et al., Amir S., Milo L., Adar R., Chapal Ilani I. N., Berman V., Fried Y., Ainbinder E., Cohen G., Barr H. M., Halaban R., Shapiro E. (2016), Genome Research. 26, 11, p. 1588-1599   |  All authors

  • Digoxin derivatives with selectivity for the alpha2beta3 isoform of Na,K-ATPase potently reduce intraocular pressure.

    Katz A., Tal D. M., Heller D. et al., Habeck M., Ben-Zeev E., Rabah B., Bar Kana K. Y., Marcovich A. L., Karlish S. J. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13723-8   |  All authors

  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Ben Chetrit C. N., Chetrit D., Russell R. et al., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M., Yarden Y. (2015), Science Signaling. 8, 360, ra7   |  All authors