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All Publications

  • Dual targeting of histone deacetylases and myc as potential treatment strategy for h3- k27m pediatric gliomas

    Authors: Algranati D., Oren R., Dassa B., Fellus-Alyagor L., Plotnikov A., Barr H., Harmelin A., London N., Ron G., Furth N. & Shema E. (2024), eLife. 13, RP96257

  • Targeting phenylalanine assemblies as a prospective disease-modifying therapy for phenylketonuria

    Authors: Shaham-Niv S., Ezra A., Zaguri D., Shotan S. R., Haimov E., Engel H., Brider T., Simhaev L., Barr H. M., Adler-Abramovich L. & Gazit E. (2024), Biophysical Chemistry. 308, 107215

  • High throughput screening identifies broad-spectrum Coronavirus entry inhibitors

    Authors: Khan S., Partuk E. O., Chiaravalli J., Kozer N., Shurrush K. A., Elbaz-Alon Y., Scher N., Giraud E., Tran-Rajau J., Agou F., Barr H. M. & Avinoam O. (2024), iScience. 27, 6, 110019

  • Enabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements

    Authors: Griffen E. J., Boulet P., Albrecht R., Akbar A., Amick I., Aschenbrenner J. C., Balcomb B. H., Barr H., Battu H., Benjamin J., Livnah E., London N., Tivon B., Resnick E., Reddi R. N., Gabizon R., Cohen G., Solmesky L. J., Vitner E. B. & Yahalom-Ronen Y. (2024), Wellcome Open Research. 9, 374

  • Structureactivity relationship study of small-molecule inhibitor of Atg12-Atg3 proteinprotein interaction

    Authors: Skach K., Boserle J., Břehová P., Chaloupecká E., Nencka R., Skach K., Nuta G. C., Bialik S., Kimchi A., Carvalho S., Kozer N. & Barr H. (2024), Bioorganic and Medicinal Chemistry Letters. 112, 129939

  • A high-throughput zebrafish screen identifies novel candidate treatments for Kaposiform Lymphangiomatosis (KLA)

    Authors: Bassi I., Jabali A., Farag N., Egozi S., Moshe N., Leichner G. S., Geva P., Levin L., Barzilai A., Avivi C., Long J., Otterstrom J. J., Paran Y., Barr H., Yaniv K. & Greenberger S. (2024), BioRxiv.

  • Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure

    Authors: Su M., Fleischer T., Grosheva I., Horev M. B., Olszewska M., Mattioli C. C., Barr H., Plotnikov A., Carvalho S., Moskovich Y., Minden M. D., Chapal-Ilani N., Wainstein A., Papapetrou E. P., Dezorella N., Cheng T., Kaushansky N., Geiger B. & Shlush L. I. (2024), iScience. 27, 4, 109443

  • Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction

    Authors: Nuta G. C., Gilad Y., Goldberg N., Meril S., Bahlsen M., Carvalho S., Kozer N., Barr H., Fridmann Sirkis Y., Hercík K., Břehová P., Nencka R., Bialik S., Eisenstein M. & Kimchi A. (2023), Autophagy. 19, 8, p. 2372-2385

  • Correction: A duplex structure of SARM1 octamers stabilized by a new inhibitor (Cellular and Molecular Life Sciences, (2023), 80, 1, (16), 10.1007/s00018-022-04641-3)

    Authors: Khazma T., Golan-Vaishenker Y., Guez-Haddad J., Grossman A., Sain R., Weitman M., Plotnikov A., Zalk R., Yaron A., Hons M. & Opatowsky Y. (2023),

  • Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

    Authors: Boby M. L., Fearon D., Ferla M., Filep M., Koekemoer L., Robinson M. C., Chodera J. D., Lee A. A., London N., von Delft A., Barr H., Ben-Shmuel A., Cohen G., Erez N., Gabizon R., Reddi R. N., Resnick E., Tamir H., Vitner E. B. & Yahalom-Ronen Y. (2023), Science (New York, N.Y.). 382, 6671, eabo7201

  • Azapeptide activity-based probes for the SARS-CoV-2 main protease enable visualization of inhibition in infected cells

    Authors: Vanhoutte R., Barniol-Xicota M., Chiu W., Vangeel L., Jochmans D., De Jonghe S., Zidane H., Barr H. M., London N., Neyts J. & Verhelst S. H. (2023), Chemical science (Cambridge). 14, 7, p. 1666-1672

  • Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimers disease phenotype in mice

    Authors: Gould N. L., Scherer G. R., Carvalho S., Shurrush K., Kayyal H., Edry E., Elkobi A., David O., Foqara M., Thakar D., Pavesi T., Sharma V., Walker M., Maitland M., Dym O., Albeck S., Peleg Y., Germain N., Babaev I., Sharir H., Lalzar M., Shklyar B., Hazut N., Khamaisy M., Lévesque M., Lajoie G., Avoli M., Amitai G., Lefker B., Subramanyam C., Shilton B., Barr H. & Rosenblum K. (2023), Journal of Clinical Investigation. 133, 19, e162120

  • Turning high-throughput structural biology into predictive inhibitor design

    Authors: Saar K. L., McCorkindale W., Fearon D., Boby M., Barr H., Ben-Shmuel A., London N., von Delft F., Chodera J. D. & Lee A. A. (2023), Proceedings of the National Academy of Sciences of the United States of America. 120, 11, e221416812

  • A duplex structure of SARM1 octamers stabilized by a new inhibitor

    Authors: Khazma T., Golan-Vaishenker Y., Guez-Haddad J., Grossman A., Sain R., Weitman M., Plotnikov A., Zalk R., Yaron A., Hons M. & Opatowsky Y. (2023), Cellular and Molecular Life Sciences. 80, 1, 16

  • Sulfamate Acetamides as Self-Immolative Electrophiles for Covalent Ligand-Directed Release Chemistry

    Authors: Reddi R. N., Rogel A., Gabizon R., Rawale D. G., Harish B., Marom S., Tivon B., Arbel Y. S., Gurwicz N., Oren R., David K., Liu J., Duberstein S., Itkin M., Malitsky S., Barr H., Katz B., Herishanu Y., Shachar I., Shulman Z. & London N. (2023), Journal of the American Chemical Society. 145, 6, p. 3346-3360

  • Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells

    Authors: Wallis N., Oberman F., Shurrush K., Germain N., Greenwald G., Gershon T., Pearl T., Abis G., Singh V., Singh A., Sharma A. K., Barr H. M., Ramos A., Spiegelman V. S. & Yisraeli J. K. (2022), RNA Biology. 19, 1, p. 26-43

  • SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids

    Authors: Jansen J., Reimer K. C., Nagai J. S., Varghese F. S., Overheul G. J., de Beer M., Roverts R., Daviran D., Fermin L. A., Willemsen B., Beukenboom M., Barr H., Cohen G., Gabizon R., London N., Reddi R. N., Resnick E., Solmesky L. J., Vitner E. B. & Yahalom-Ronen Y. (2022), Cell Stem Cell. 29, 2, p. 217-231.e8

  • Optimization of Covalent MKK7 Inhibitors via Crude Nanomole-Scale Libraries

    Authors: Gehrtz P., Marom S., Bührmann M., Hardick J., Kleinbölting S., Shraga A., Dubiella C., Gabizon R., Wiese J. N., Müller M. P., Cohen G., Babaev I., Shurrush K., Avram L., Resnick E., Barr H., Rauh D. & London N. (2022), Journal of Medicinal Chemistry. 65, 15, p. 10341-10356

  • Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2a-phosphorylation

    Authors: Sehrawat U., Haimov O., Weiss B., Tamarkin-Ben Harush A., Ashkenazi S., Plotnikov A., Noiman T., Leshkowitz D., Stelzer G. & Dikstein R. (2022), Proceedings of the National Academy of Sciences - PNAS. 119, 30, e212033911

  • Site-Specific Labeling of Endogenous Proteins Using CoLDR Chemistry

    Authors: Reddi R. N., Rogel A., Resnick E., Gabizon R., Prasad P. K., Gurwicz N., Barr H., Shulman Z. & London N. (2021), Journal of the American Chemical Society. 143, 48, p. 20095-20108

  • Tunable Methacrylamides for Covalent Ligand Directed Release Chemistry

    Authors: Reddi R. N., Resnick E., Rogel A., Rao B. V., Gabizon R., Goldenberg K., Gurwicz N., Zaidman D., Plotnikov A., Barr H., Shulman Z. & London N. (2021), Journal of the American Chemical Society. 143, 13, p. 4979-4992

  • Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine

    Authors: Beharier O., Plitman Mayo R., Raz T., Nahum Sacks K., Schreiber L., Suissa-Cohen Y., Chen R., Gomez-Tolub R., Hadar E., Gabbay-Benziv R., Jaffe Moshkovich Y., Biron-Shental T., Shechter-Maor G., Farladansky-Gershnabel S., Yitzhak Sela H., Benyamini-Raischer H., Sela N. D., Goldman-Wohl D., Shulman Z., Many A., Barr H., Yagel S., Neeman M. & Kovo M. (2021), Journal of Clinical Investigation. 131, 13, e150319

  • An automatic pipeline for the design of irreversible derivatives identifies a potent SARS-CoV-2 Mpro inhibitor

    Authors: Zaidman D., Prilusky J., Cohen G., Resnick E., Barr H. & London N. (2021), Cell Chemical Biology. 28, 12, p. 1795-1806

  • Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

    Authors: Amitai G., Plotnikov A., Chapman S., Lazar S., Gez R., Loewenthal D., Shurrush K. A., Cohen G., Solmesky L. J., Barr H. & Russell A. J. (2021), Communications Biology. 4, 573

  • Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

    Authors: Kinker G. S., Greenwald A. C., Tal R., Orlova Z., Cuoco M. S., McFarland J. M., Warren A., Rodman C., Roth J. A., Bender S. A., Kumar B., Rocco J. W., Fernandes P. A., Mader C. C., Keren-Shaul H., Plotnikov A., Barr H., Tsherniak A., Rozenblatt-Rosen O., Krizhanovsky V., Puram S. V., Regev A. & Tirosh I. (2020), Nature Genetics. 52, 11, p. 1208-1218

  • Structural basis for producing selective MAP2K7 inhibitors

    Authors: Murakawa Y., Valter S., Barr H., London N. & Kinoshita T. (2020), Bioorganic and Medicinal Chemistry Letters. 30, 22, 127546

  • Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments

    Authors: Snitser O., Russ D., Stone L. K., Wang K. K., Sharir H., Kozer N., Cohen G., Barr H. M. & Kishony R. (2020), Nature Communications. 11, 1, 6038

  • Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

    Authors: Tavor S., Shalit T., Chapal Ilani N., Moskovitz Y., Livnat N., Groner Y., Barr H., Minden M. D., Plotnikov A., Deininger M. W., Kaushansky N. & Shlush L. I. (2020), Haematologica. 105, 12, p. 2795-2804

  • MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy

    Authors: Cerqueira F. M., Kozer N., Petcherski A., Baranovski B. M., Wolf D., Assali E. A., Roth Y., Gazit R., Barr H., Lewis E. C., Las G. & Shirihai O. S. (2020), Biochemical Journal. 477, 2, p. 461-475

  • PRMT1 inhibition induces differentiation of colon cancer cells

    Authors: Plotnikov A., Kozer N., Cohen G., Carvalho S., Duberstein S., Almog O., Solmesky L. J., Shurrush K. A., Babaev I., Benjamin S., Gilad S., Kupervaser M., Levin Y., Gershovits M., Ben-Avraham D. & Barr H. M. (2020), Scientific Reports. 10, 1, 20030

  • Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Authors: Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. (2019), Cell Chemical Biology. 26, 1, p. 98 - 108

  • An Efficient One-Pot Enzymatic Synthesis of Cardiac Glycosides with Varied Sugar Chain Lengths

    Authors: Huang W., Wen C., Zhou Z., Fu Z., Katz A., Plotnikov A., Karlish S. J. D. & Jiang R. (2019), Advanced Synthesis & Catalysis. 361, 13, p. 3114-3119

  • Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation

    Authors: Plotnikov A., Chuderland D., Karamansha Y., Livnah O. & Seger R. (2019), Cellular Physiology and Biochemistry. 53, 2, p. 366-387

  • Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

    Authors: Resnick E., Bradley A., Gan J., Douangamath A., Krojer T., Sethi R., Geurink P. P., Aimon A., Amitai G., Bellini D., Bennett J., Fairhead M., Fedorov O., Gabizon R., Gan J., Gu J., Plotnikov A., Reznik N., Ruda G. F., Diaz-Saez L., Straub V. M., Szommer T., Velupillai S., Zaidman D., Zhang Y., Coker A. R., Dowson C. G., Barr H. M., Wang C., Huber K. V. M., Brennan P. E., Ovaa H., von Delft F. & London N. (2019), Journal of the American Chemical Society. 141, 22, p. 8951-8968

  • The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

    Authors: Yifa O., Weisinger K., Bassat E., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brenner O., Bursac N. & Tzahor E. (2019), JCI insight. 4, 22, e128025

  • Targeting Spt5-Pol II by Small-Molecule Inhibitors Uncouples Distinct Activities and Reveals Additional Regulatory Roles

    Authors: Bahat A., Lahav O., Plotnikov A., Leshkowitz D. & Dikstein R. (2019), Molecular Cell. 76, 4, p. 617-631

  • Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

    Authors: Reznik N., Kozer N., Eisenberg-Lerner A., Barr H., Merbl Y. & London N. (2019), ACS Chemical Biology. 14, 12, p. 2538-2545

  • High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

    Authors: Yardeni T., Fine R., Joshi Y., Gradus-Pery T., Kozer N., Reichenstein I., Yanowski E., Nevo S., Weiss-Tishler H., Eisenberg-Bord M., Shalit T., Plotnikov A., Barr H. M., Perlson E. & Hornstein E. (2018), Scientific Reports. 8, 1, 59

  • Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases

    Authors: Sapir T., Levy T., Kozer N., Shin I., Zamor V., Haffner-Krausz R., McGlade J. C. & Reiner O. (2018), Cerebral Cortex. 28, 9, p. 3115-3128

  • A multiplexed screening method for pluripotency

    Authors: Plotnikov A., Kozer N., Krupalnik V., Peles S., Mor N., Rais Y., Hanna J. H. & Barr H. M. (2017), Stem Cell Research. 23, p. 158-162

  • Effective cell-free drug screening protocol for protein-protein interaction

    Authors: Ashkenazi S., Plotnikov A., Bahat A. & Dikstein R. (2017), Analytical Biochemistry. 532, p. 53-59

  • Protein recognition by a pattern-generating fluorescent molecular probe

    Authors: Pode Z., Peri-Naor R., Georgeson J. M., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L. & Margulies D. (2017), Nature Nanotechnology. 12, 12, p. 1161-1168

  • A novel allosteric mechanism of NF-κB dimerization and DNA binding targeted by an anti-inflammatory drug

    Authors: Ashkenazi S., Plotnikov A., Bahat A., Ben-Zeev E., Warszawski S. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 8, p. 1237-1247

  • A generic, cost-effective, and scalable cell lineage analysis platform

    Authors: Biezuner T., Spiro A., Raz O., Amir S., Milo L., Adar R., Chapal Ilani I. N., Berman V., Fried Y., Ainbinder E., Cohen G., Barr H. M., Halaban R. & Shapiro E. (2016), Genome Research. 26, 11, p. 1588-1599

  • Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure

    Authors: Katz A., Tal D. M., Heller D., Habeck M., Ben-Zeev E., Rabah B., Bar Kana K. Y., Marcovich A. L. & Karlish S. J. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13723-13728

  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Authors: Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Lapidot T., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. (2015), Science Signaling. 8, 360, ra7