All Publications

  • Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity

    Authors: Kinker G. S., Greenwald A. C., Tal R., Orlova Z., Cuoco M. S., McFarland J. M., Warren A., Rodman C., Roth J. A., Bender S. A., Kumar B., Rocco J. W., Fernandes P. A., Mader C. C., Keren-Shaul H., Plotnikov A., Barr H., Tsherniak A., Rozenblatt-Rosen O., Krizhanovsky V., Puram S. V., Regev A. & Tirosh I. (2020), Nature Genetics. 52, 11, p. 1208-1218
  • Structural basis for producing selective MAP2K7 inhibitors

    Authors: Murakawa Y., Valter S., Barr H., London N. & Kinoshita T. (2020), Bioorganic and Medicinal Chemistry Letters. 30, 22, 127546
  • Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments

    Authors: Snitser O., Russ D., Stone L. K., Wang K. K., Sharir H., Kozer N., Cohen G., Barr H. M. & Kishony R. (2020), Nature Communications. 11, 1, 6038
  • MitoTimer-based high-content screen identifies two chemically-related benzothiophene derivatives that enhance basal mitophagy

    Authors: Cerqueira F. M., Kozer N., Petcherski A., Baranovski B. M., Wolf D., Assali E. A., Roth Y., Gazit R., Barr H., Lewis E. C., Las G. & Shirihai O. S. (2020), Biochemical Journal. 477, 2, p. 461-475
  • PRMT1 inhibition induces differentiation of colon cancer cells

    Authors: Plotnikov A., Kozer N., Cohen G., Carvalho S., Duberstein S., Almog O., Solmesky L. J., Shurrush K. A., Babaev I., Benjamin S., Gilad S., Kupervaser M., Levin Y., Gershovits M., Ben-Avraham D. & Barr H. M. (2020), Scientific Reports. 10, 1, 20030
  • Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor

    Authors: Shraga A., Olshvang E., Davidzohn N., Khoshkenar P., Germain N., Shurrush K., Carvalho S., Avram L., Albeck S., Unger T., Lefker B., Subramanyam C., Hudkins R. L., Mitchell A., Shulman Z., Kinoshita T. & London N. (2019), Cell Chemical Biology. 26, 1, p. 98 - 108
  • An Efficient One-Pot Enzymatic Synthesis of Cardiac Glycosides with Varied Sugar Chain Lengths

    Authors: Huang W., Wen C., Zhou Z., Fu Z., Katz A., Plotnikov A., Karlish S. J. D. & Jiang R. (2019), Advanced Synthesis & Catalysis. 361, 13, p. 3114-3119
  • Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening

    Authors: Resnick E., Bradley A., Gan J., Douangamath A., Krojer T., Sethi R., Geurink P. P., Aimon A., Amitai G., Bellini D., Bennett J., Fairhead M., Fedorov O., Gabizon R., Gan J., Gu J., Plotnikov A., Reznik N., Ruda G. F., Diaz-Saez L., Straub V. M., Szommer T., Velupillai S., Zaidman D., Zhang Y., Coker A. R., Dowson C. G., Barr H. M., Wang C., Huber K. V. M., Brennan P. E., Ovaa H., von Delft F. & London N. (2019), Journal of the American Chemical Society. 141, 22, p. 8951-8968
  • The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice

    Authors: Yifa O., Weisinger K., Bassat E., Li H., Kain D., Barr H., Kozer N., Genzelinakh A., Rajchman D., Eigler T., Umansky K. B., Lendengolts D., Brener O., Bursac N. & Tzahor E. (2019), JCI insight. 4, 22, 128025
  • Targeting Spt5-Pol II by Small-Molecule Inhibitors Uncouples Distinct Activities and Reveals Additional Regulatory Roles

    Authors: Bahat A., Lahav O., Plotnikov A., Leshkowitz D. & Dikstein R. (2019), Molecular Cell. 76, 4, p. 617-631
  • Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression

    Authors: Reznik N., Kozer N., Eisenberg-Lerner A., Barr H., Merbl Y. & London N. (2019), ACS Chemical Biology. 14, 12, p. 2538-2545
  • High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

    Authors: Yardeni T., Fine R., Joshi Y., Gradus-Pery T., Kozer N., Reichenstein I., Yanowski E., Nevo S., Weiss-Tishler H., Eisenberg-Bord M., Shalit T., Plotnikov A., Barr H. M., Perlson E. & Hornstein E. (2018), Scientific Reports. 8, 59
  • Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases

    Authors: Sapir T., Levy T., Kozer N., Shin I., Zamor V., Haffner-Krausz R., McGlade J. C. & Reiner O. (2018), Cerebral Cortex. 28, 9, p. 3115-3128
  • A multiplexed screening method for pluripotency

    Authors: Plotnikov A., Kozer N., Krupalnik V., Peles S., Mor N., Rais Y., Hanna J. H. & Barr H. M. (2017), Stem Cell Research. 23, p. 158-162
  • Effective cell-free drug screening protocol for protein-protein interaction

    Authors: Ashkenazi S., Plotnikov A., Bahat A. & Dikstein R. (2017), Analytical Biochemistry. 532, p. 53-59
  • Protein recognition by a pattern-generating fluorescent molecular probe

    Authors: Pode Z., Peri-Naor R., Georgeson J. M., Ilani T., Kiss V., Unger T., Markus B., Barr H. M., Motiei L. & Margulies D. (2017), Nature Nanotechnology. 12, 12, p. 1161-1168
  • A Novel Allosteric Mechanism of NF-kappaB Dimerization and DNA Binding Targeted by an Anti-Inflammatory Drug.

    Authors: Ashkenazi S., Plotnikov A., Bahat A., Ben-Zeev E., Warszawski S. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 8, p. 1237-1247
  • A generic, cost-effective, and scalable cell lineage analysis platform

    Authors: Biezuner T., Spiro A., Raz O., Amir S., Milo L., Adar R., Chapal Ilani I. N., Berman V., Fried Y., Ainbinder E., Cohen G., Barr H. M., Halaban R. & Shapiro E. (2016), Genome Research. 26, 11, p. 1588-1599
  • Digoxin derivatives with selectivity for the alpha2beta3 isoform of Na,K-ATPase potently reduce intraocular pressure.

    Authors: Katz A., Tal D. M., Heller D., Habeck M., Ben-Zeev E., Rabah B., Bar Kana K. Y., Marcovich A. L. & Karlish S. J. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13723-13728
  • Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer

    Authors: Ben Chetrit C. N., Chetrit D., Russell R., Koerner C., Mancini M., Abdul-Hai A., Itkin T., Carvalho S., Cohen-Dvashi H., Koestler W. J., Shukla K., Lindzen M., Kedmi M., Lauriola M., Shulman Z., Barr H., Seger D., Ferraro D. A., Pareja F., Gil-Henn H., Lapidot T., Alon R., Milanezi F., Symons M., Ben Hamo H. R., Efroni S., Schmitt F., Wiemann S., Caldas C., Ehrlich M. & Yarden Y. (2015), Science Signaling. 8, 360, ra7