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Inhibitors of eIF1A-ribosome interaction unveil uORF-dependent regulation of translation initiation and antitumor and antiviral effects
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Targeting phenylalanine assemblies as a prospective disease-modifying therapy for phenylketonuria
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Structureactivity relationship study of small-molecule inhibitor of Atg12-Atg3 proteinprotein interaction
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Targeting SRSF2 mutations in leukemia with RKI-1447: A strategy to impair cellular division and nuclear structure
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Dual targeting of histone deacetylases and myc as potential treatment strategy for h3- k27m pediatric gliomas
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Identifying a selective inhibitor of autophagy that targets ATG12-ATG3 protein-protein interaction
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Correction: A duplex structure of SARM1 octamers stabilized by a new inhibitor (Cellular and Molecular Life Sciences, (2023), 80, 1, (16), 10.1007/s00018-022-04641-3)
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Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors
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Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimers disease phenotype in mice
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SARS-CoV-2 infects the human kidney and drives fibrosis in kidney organoids
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Inhibitors of eIF4G1-eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2a-phosphorylation
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Efficient maternal to neonatal transfer of antibodies against SARS-CoV-2 and BNT162b2 mRNA COVID-19 vaccine
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Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase
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Structural basis for producing selective MAP2K7 inhibitors
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Ubiquitous selection for mecA in community-associated MRSA across diverse chemical environments
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PRMT1 inhibition induces differentiation of colon cancer cells
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Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature
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Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity
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Phenotypic Screen Identifies JAK2 as a Major Regulator of FAT10 Expression
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The small molecule Chicago Sky Blue promotes heart repair following myocardial infarction in mice
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Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening
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Nuclear ERK translocation is mediated by protein kinase CK2 and accelerated by autophosphorylation
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An Efficient One-Pot Enzymatic Synthesis of Cardiac Glycosides with Varied Sugar Chain Lengths
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Covalent Docking Identifies a Potent and Selective MKK7 Inhibitor
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High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria
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Notch Activation by Shootin1 Opposing Activities on 2 Ubiquitin Ligases
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Effective cell-free drug screening protocol for protein-protein interaction
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A novel allosteric mechanism of NF-κB dimerization and DNA binding targeted by an anti-inflammatory drug
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A generic, cost-effective, and scalable cell lineage analysis platform
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Synaptojanin 2 is a druggable mediator of metastasis and the gene is overexpressed and amplified in breast cancer
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Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure