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  • A Non-Canonical role of cGMP Links PDE5A Inhibition to Metastasis Suppression

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  • Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point-Mutation-Mediated Resistance

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  • Myeloid derived suppressor cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection

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  • LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea

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  • Proteomics analysis of the brain from a Gaucher disease mouse identifies pathological pathways including a possible role for transglutaminase 1

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  • Repurposing of glatiramer acetate to treat cardiac ischemia in rodent models

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  • Conventional type 1 dendritic cells are essential for the development of primary biliary cholangitis

    Authors: Reuveni D., Assi S., Gore Y., Brazowski E., Leung P. S., Shalit T., Gershwin M. E. & Zigmond E. (2024), Liver International. 44, 8, p. 2063-2074
  • Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates

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  • Chiral Fluorescent Antifungal Azole Probes Detect Resistance, Uptake Dynamics, and Subcellular Distribution in Candida Species

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  • Author Correction: Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis (Nature Communications, (2022), 13, 1, (7199), 10.1038/s41467-022-34863-9)

    Authors: Aylon Y., Furth N., Mallel G., Friedlander G., Nataraj N. B., Dong M., Hassin O., Zoabi R., Cohen B., Drendel V., Salame T. M., Mukherjee S., Harpaz N., Johnson R., Aulitzky W. E., Yarden Y., Shema E. & Oren M. (2023),
  • Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

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  • Differential gene expression in the calvarial and cortical bone of juvenile female mice

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  • DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells

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  • Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea

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  • CD74 as a regulator of transcription in normal B cells

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  • Macrophage-Secreted CSF1 Transmits a Calorie Restriction-Induced Self-Renewal Signal to Mammary Epithelial Stem Cells

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  • Exposure to naphthalene and β-pinene-derived secondary organic aerosol induced divergent changes in transcript levels of BEAS-2B cells

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  • Genomic structural plasticity of rodent-associated Bartonella in nature

    Authors: de Sousa K. C. M., Gutiérrez R., Yahalomi D., Shalit T., Markus B., Nachum-Biala Y., Hawlena H., Marcos-Hadad E., Hazkani-Covo E., de Rezende Neves H. H., Covo S. & Harrus S. (2022), Molecular Ecology. 31, 14, p. 3784-3797
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  • Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

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  • ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

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  • IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

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  • CD74 is a regulator of hematopoietic stem cell maintenance

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  • Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs

    Authors: Valiulahi P., Vidyawan V., Puspita L., Oh Y., Juwono V. B., Sittipo P., Friedlander G., Yahalomi D., Sohn J. W., Lee Y. K., Yoon J. K. & Shim J. w. (2021), Stem Cell Reports. 16, 8, p. 1938-1952
  • β-sitosterol reduces anxiety and synergizes with established anxiolytic drugs in mice

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  • Inhibition of cysteine proteases by 6,6dihydroxythiobinupharidine (Dtbn) from nuphar lutea

    Authors: Waidha K., Zurgil U., Benzeev E., Gopas J., Rajendran S. & Golangoldhirsh A. (2021), Molecules. 26, 16, 4743
  • Tent4a noncanonical poly(A) polymerase regulates dnadamage tolerance via multiple pathways that are mutated in endometrial cancer

    Authors: Swain U., Friedlander G., Sehrawat U., Sarusiportuguez A., Rotkopf R., Ebert C., Pazelizur T., Dikstein R., Carell T., Geacintov N. E. & Livneh Z. (2021), International Journal of Molecular Sciences. 22, 13, 6957
  • Phylogeny and abiotic conditions shape the diel floral emission patterns of desert Brassicaceae species

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  • Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

    Authors: Basavaraja R., Drum J. N., Sapuleni J., Bibi L., Friedlander G., Kumar S., Sartori R. & Meidan R. (2021), BMC Genomics. 22, 1, 452
  • Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

    Authors: Shitrit A., Zaidman D., Kalid O., Bloch I., Doron D., Yarnizky T., Buch I., Segev I., Ben-Zeev E., Segev E. & Kobiler O. (2020), Scientific Reports. 10, 1, 20808
  • CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

    Authors: Fuzesi-Levi M. G., Fainer I., Enchev R. I., Ben-Nissan G., Levin Y., Kupervaser M., Friedlander G., Salame T. M., Nevo R., Peter M. & Sharon M. (2020), Cell Death and Differentiation. 27, 3, p. 984-998
  • The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis

    Authors: Rabinovich S., Silberman A., Adler L., Agron S., Levin-Zaidman S., Bahat A., Porat Z., Ben-Zeev E., Geva I., Itkin M., Malitsky S., Buchaklian A., Helbling D., Dimmock D. & Erez A. (2020), Oncogene. 39, 1, p. 164-175
  • Nanobodies Targeting Prostate-specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer

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  • Bartonella kosoyi sp. nov. and Bartonella krasnovii sp. nov., two novel species closely related to the zoonotic Bartonella elizabethae, isolated from black rats and wild desert rodent-fleas

    Authors: Gutierrez R., Shalit T., Markus B., Yuan C., Nachum-Biala Y., Elad D. & Harrus S. (2020), International Journal of Systematic and Evolutionary Microbiology. 70, 3, p. 1656-1665, 003952
  • Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

    Authors: Tavor S., Shalit T., Ilani N. C., Moskovitz Y., Livnat N., Groner Y., Barr H., Minden M. D., Plotnikov A., Deininger M. W., Kaushansky N. & Shlush L. I. (2020), Haematologica. 105, 12, p. 2795-2804
  • The transcriptional profile of circulating myeloid derived suppressor cells correlates with tumor development and progression in mouse

    Authors: Nachmany I., Bogoch Y., Friedlander-Malik G., Amar O., Bondar E., Zohar N., Hantisteanu S., Fainaru O., Lubezky N., Klausner J. M. & Pencovich N. (2019), Genes and Immunity. 20, 7, p. 589-598
  • Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain

    Authors: Sapiro A. L., Shmueli A., Henry G. L., Li Q., Shalit T., Yaron O., Paas Y., Li J. B. & Shohat-Ophir G. (2019), Proceedings of the National Academy of Sciences of the United States of America. 116, 6, p. 2318-2327
  • Heterochronic regulation of lung development via the Lin28-Let-7 pathway

    Authors: Gulman N. K., Armon L., Shalit T. & Urbach A. (2019), FASEB Journal. 33, 11, p. 12008-12018
  • SLAMF9 regulates pDC homeostasis and function in health and disease

    Authors: Sever L., Radomir L., Strim K., Weiner A., Shchottlender N., Lewinsky H., Barak A. F., Friedlander G., Ben-Dor S., Becker-Herman S. & Shachar I. (2019), Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16489-16496
  • Transcriptome analysis highlights nuclear control of chloroplast development in the shoot apex

    Authors: Dalal V., Dagan S., Friedlander G., Aviv E., Bock R., Charuvi D., Reich Z. & Adam Z. (2018), Scientific Reports. 8, 1, 8881
  • The Toll Pathway in the Central Nervous System of Flies and Mammals

    Authors: Shmueli A., Shalit T., Okun E. & Shohat-Ophir G. (2018), NeuroMolecular Medicine. 20, 4, p. 419-436
  • Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

    Authors: Cohen I., Naftaly S., Ben-Zeev E., Hockla A., Radisky E. S. & Papo N. (2018), Biochemical Journal. 475, 7, p. 1335-1352
  • High content image analysis reveals function of miR-124 upstream of Vimentin in regulating motor neuron mitochondria

    Authors: Yardeni T., Fine R., Joshi Y., Gradus-Pery T., Kozer N., Reichenstein I., Yanowski E., Nevo S., Weiss-Tishler H., Eisenberg-Bord M., Shalit T., Plotnikov A., Barr H. M., Perlson E. & Hornstein E. (2018), Scientific Reports. 8, 1, 59
  • Coordination of meristem doming and the floral transition by late termination, a kelch repeat protein

    Authors: Tal L., Friedlander G., Gilboa N. S., Unger T., Gilad S. & Eshed Y. (2017), Plant Cell. 29, 4, p. 681-696
  • CD74 is a novel transcription regulator

    Authors: Gil-Yarom N., Radomir L., Sever L., Kramer M. P., Lewinsky H., Bornstein C., Blecher-Gonen R., Barnett Itzhaki Z., Mirkin V., Friedlander G., Shvidel L., Herishanu Y., Lolis E. J., Becker Herman S., Amit I. & Shachar I. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 562-567
  • The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel

    Authors: Wekselman I., Zimmerman E., Davidovich C., Belousoff M., Matzov D., Krupkin M., Rozenberg H., Bashan A., Friedlander G., Kjeldgaard J., Ingmer H., Lindahl L., Zengel J. M. & Yonath A. (2017), Structure. 25, 8, p. 1233-1241.e3
  • Seasonal heat stress affects adipose tissue proteome toward enrichment of the Nrf2-mediated oxidative stress response in late-pregnant dairy cows

    Authors: Zachut M., Kra G., Livshitz L., Portnick Y., Yakoby S., Friedlander G. & Levin Y. (2017), Journal of Proteomics. 158, p. 52-61
  • A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

    Authors: Banerjee V., Oren O., Ben-Zeev E., Taube R., Engel S. & Papo N. (2017), Journal of Biological Chemistry. 292, 38, p. 15777-15788
  • Augmented expression of RUNX1 deregulates the global gene expression of U87 glioblastoma multiforme cells and inhibits tumor growth in mice

    Authors: Bogoch Y., Friedlander-Malik G., Lupu L., Bondar E., Zohar N., Langier S., Ram Z., Nachmany I., Klausner J. M. & Pencovich N. (2017), Tumor Biology. 39, 4
  • Proteome dataset of subcutaneous adipose tissue obtained from late pregnant dairy cows during summer heat stress and winter seasons

    Authors: Zachut M., Kra G., Livshitz L., Portnick Y., Yakoby S., Friedlander G. & Levin Y. (2017), Data in Brief. 12, p. 535-539
  • Digoxin derivatives with selectivity for the alpha 2 beta 3 isoform of Na,K-ATPase potently reduce intraocular pressure

    Authors: Heller D., Marcovich A., Katz A., Tal D. M., Habeck M., Ben-Zeev E., Rabah B., Barkana Y. & Karlish S. J. (2016),
  • Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cells

    Authors: Yoffe Y., David M., Kalaora R., Povodovski L., Friedlander G., Feldmesser E., Ainbinder E., Saada A., Bialik S. & Kimchi A. (2016), Genes and Development. 30, 17, p. 1991-2004
  • A novel allosteric mechanism of NF-κB dimerization and DNA binding targeted by an anti-inflammatory drug

    Authors: Ashkenazi S., Plotnikov A., Bahat A., Ben-Zeev E., Warszawski S. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 8, p. 1237-1247
  • Selective assembly of Na,K-ATPase α2 β2 Heterodimers in the Heart: Distinct functional properties and isoform-selective inhibitors

    Authors: Habeck M., Tokhtaeva E., Nadav Y., Zeev E. B., Ferris S. P., Kaufman R. J., Bab-Dinitz E., Kaplan J. H., Dada L. A., Farfel Z., Tal D. M., Katz A., Sachs G., Vagin O. & Karlish S. J. (2016), Journal of Biological Chemistry. 291, 44, p. 23159-23174
  • Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experiment

    Authors: Lensink M. F., Velankar S., Kryshtafovych A., Huang S. Y., Schneidman-Duhovny D., Sali A., Segura J., Fernandez-Fuentes N., Viswanath S., Elber R., Grudinin S., Popov P., Neveu E., Lee H., Baek M., Park S., Heo L., Lee G. R., Seok C., Qin S., Zhou H. X., Ritchie D. W., Maigret B., Devignes M. D., Ghoorah A., Torchala M., Chaleil R. A., Bates P. A., Ben-Zeev E., Eisenstein M., Negi S. S., Weng Z., Vreven T., Pierce B. G., Borrman T. M., Yu J., Ochsenbein F., Guerois R., Vangone A., Rodrigues J. P., Van Zundert G., Nellen M., Xue L., Karaca E., Melquiond A. S., Visscher K., Kastritis P. L., Bonvin A. M., Xu X., Qiu L., Yan C., Li J., Ma Z., Cheng J., Zou X., Shen Y., Peterson L. X., Kim H. R., Roy A., Han X., Esquivel-Rodriguez J., Kihara D., Yu X., Bruce N. J., Fuller J. C., Wade R. C., Anishchenko I., Kundrotas P. J., Vakser I. A., Imai K., Yamada K., Oda T., Nakamura T., Tomii K., Pallara C., Romero-Durana M., Jiménez-García B., Moal I. H., Férnandez-Recio J., Joung J. Y., Kim J. Y., Joo K., Lee J., Kozakov D., Vajda S., Mottarella S., Hall D. R., Beglov D., Mamonov A., Xia B., Bohnuud T., Del Carpio C. A., Ichiishi E., Marze N., Kuroda D., Roy Burman S. S., Gray J. J., Chermak E., Cavallo L., Oliva R., Tovchigrechko A. & Wodak S. J. (2016), Proteins: Structure, Function and Bioinformatics. 84, p. 323-348
  • A metabolic gene cluster in the wheat W1 and the barley Cer-cqu loci determines β-diketone biosynthesis and glaucousness

    Authors: Hen-Avivi S., Savin O., Racovita R. C., Lee W. S., Adamski N. M., Malitsky S., Almekias-Siegl E., Levy M., Vautrin S., Bergès H., Friedlander G., Kartvelishvily E., Ben-Zvi G., Alkan N., Uauy C., Kanyuka K., Jetter R., Distelfeld A. & Aharoni A. (2016), Plant Cell. 28, 6, p. 1440-1460
  • Using synthetic mouse spike-in transcripts to evaluate RNA-seq analysis tools

    Authors: Leshkowitz D., Feldmesser E., Friedlander G., Jona G., Ainbinder E., Parmet Y. & Horn-Saban S. (2016), PLoS ONE. 11, 4, e0153782
  • Simultaneous transcriptome analysis of Colletotrichum gloeosporioides and tomato fruit pathosystem reveals novel fungal pathogenicity and fruit defense strategies

    Authors: Alkan N., Friedlander G., Ment D., Prusky D. & Fluhr R. (2015), NEW PHYTOLOGIST. 205, 2, p. 801-815
  • The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions

    Authors: Tirosh O., Cohen Y., Shitrit A., Shani O., Le-Trilling V. T. K., Trilling M., Friedlander G., Tanenbaum M. & Stern-Ginossar N. (2015), PLoS Pathogens. 11, 11, e1005288
  • Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure

    Authors: Katz A., Tal D. M., Heller D., Habeck M., Zeev E. B., Rabah B., Kana Y. B., Marcovich A. L. & Karlish S. J. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13723-13728
  • Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

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  • Strategy of transcription regulation in the budding yeast

    Authors: Levy S., Ihmels J., Carmi M., Weinberger A., Friedlander G. & Barkai N. (2014), Investigations in Yeast Functional Genomics and Molecular Biology. Eckwahl M. (eds.). p. 209-232
  • Divergent Levels of LBP and TGFβ1 in Murine MSCs Lead to Heterogenic Response to TLR and Proinflammatory Cytokine Activation

    Authors: Levin S., Pevsner-Fischer M., Kagan S., Lifshitz H., Weinstock A., Gataulin D., Friedlander G. & Zipori D. (2014), Stem Cell Reviews. 10, 3, p. 376-388
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    Authors: Lotem J., Levanon D., Negreanu V., Leshkowitz D., Friedlander G. & Groner Y. (2013), PLoS ONE. 8, 11, e80467
  • Global aspects of pacC regulation of pathogenicity genes in colletotrichum gloeosporioides as revealed by transcriptome analysis

    Authors: Alkan N., Meng X., Friedlander G., Reuveni E., Sukno S., Sherman A., Thon M., Fluhr R. & Prusky D. (2013), Molecular Plant-Microbe Interactions. 26, 11, p. 1345-1358
  • Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

    Authors: Madar S., Harel E., Goldstein I., Stein Y., Kogan-Sakin I., Kamer I., Solomon H., Dekel E., Tal P., Goldfinger N., Friedlander G. & Rotter V. (2013), PLoS ONE. 8, 4, e61353
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    Authors: Yacovan A., Ozeri R., Kehat T., Mirilashvili S., Sherman D., Aizikovich A., Shitrit A., Ben-Zeev E., Schutz N., Bohana-Kashtan O., Konson A., Behar V. & Becker O. M. (2012), Bioorganic and Medicinal Chemistry Letters. 22, 20, p. 6460-6468
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    Authors: Yifhar T., Pekker I., Peled D., Friedlander G., Pistunov A., Sabban M., Wachsman G., Alvarez J. P., Amsellem Z. & Eshed Y. (2012), Plant Cell. 24, 9, p. 3575-3589
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    Authors: Akiva E., Friedlander G., Itzhaki Z. & Margalit H. (2012), PLoS Computational Biology. 8, 1, e1002341