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All Publications

  • Retinoic acid, an essential component of the roof plate organizer, promotes the spatiotemporal segregation of dorsal neural fates

    Authors: Rekler D., Ofek S., Kagan S., Friedlander G. & Kalcheim C. (2024), Development (Cambridge). 151, 19, dev202973

  • Reshaping Echinocandin Antifungal Drugs To Circumvent Glucan Synthase Point-Mutation-Mediated Resistance

    Authors: Jospe-Kaufman M., Ben-Zeev E., Mottola A., Dukhovny A., Berman J., Carmeli S. & Fridman M. (2024), Angewandte Chemie - International Edition. 63, 9, e202314728

  • Myeloid derived suppressor cells mediate hepatocyte proliferation and immune suppression during liver regeneration following resection

    Authors: Nachmany I., Nevo S., Edelheit S., Sarusi-Portuguez A., Friedlander G., Salame T. M., Pavlov V., Yakubovsky O. & Pencovich N. (2024), Genes and Immunity.

  • LsBOS utilizes oxalyl-CoA produced by LsAAE3 to synthesize β-ODAP in grass pea

    Authors: Goldsmith M., Avram L., Brandis A., Mehlman T., Ben-Dor S., Peleg Y., Ben-Zeev E., Barbole R. S. & Reich Z. (2024),

  • Author Correction: Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis (doi 10.1038/s41467-022-34863-9 , 28 Nov, 2022)

    Authors: Aylon Y., Furth N., Mallel G., Friedlander G., Nataraj N. B., Dong M., Hassin O., Zoabi R., Cohen B., Drendel V., Salame T. M., Mukherjee S., Harpaz N., Johnson R., Aulitzky W. E., Yarden Y., Shema E. & Oren M. (2023),

  • Redifferentiated cardiomyocytes retain residual dedifferentiation signatures and are protected against ischemic injury

    Authors: Shakked A., Petrover Z., Aharonov A., Ghiringhelli M., Umansky K., Kain D., Elkahal J., Divinsky Y., Nguyen P. D., Miyara S., Friedlander G., Savidor A., Zhang L., Perez D. E., Sarig R., Lendengolts D., Bueno-Levy H., Kastan N., Levin Y., Bakkers J., Gepstein L. & Tzahor E. (2023), Nature Cardiovascular Research. 2, 4, p. 383-398

  • Newly characterized bovine mammary stromal region with epithelial properties supports representative epithelial outgrowth development from transplanted stem cells

    Authors: Kosenko A., Salame T., Fridlander G. & Barash I. (2022), Cell and Tissue Research. 387, 1, p. 39-61

  • Breast cancer plasticity is restricted by a LATS1-NCOR1 repressive axis

    Authors: Aylon Y., Furth N., Mallel G., Friedlander G., Nataraj N. B., Dong M., Hassin O., Zoabi R., Cohen B., Drendel V., Salame T. M., Mukherjee S., Harpaz N., Johnson R., Aulitzky W. E., Yarden Y., Shema E. & Oren M. (2022), Nature Communications. 13, 1, 7199

  • ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

    Authors: Fishman H., Madiwale S., Geron I., Bari V., Van Loocke W., Kirschenbaum Y., Ganmore I., Kugler E., Rein-Gil A., Friedlander G., Schiby G., Birger Y., Strehl S., Soulier J., Knoechel B., Ferrando A., Noy-Lotan S., Nagler A., Mulloy J. C., Van Vlierberghe P. & Izraeli S. (2022), Blood. 139, 3, p. 399-412

  • CD74 as a regulator of transcription in normal B cells

    Authors: David K., Friedlander G., Pellegrino B., Radomir L., Lewinsky H., Leng L., Bucala R., Becker-Herman S. & Shachar I. (2022), Cell Reports. 41, 5, 111572

  • Identification and characterization of the key enzyme in the biosynthesis of the neurotoxin β-ODAP in grass pea

    Authors: Goldsmith M., Barad S., Knafo M., Savidor A., Ben-Dor S., Brandis A., Mehlman T., Peleg Y., Albeck S., Dym O., Ben-Zeev E., Barbole R. S., Aharoni A. & Reich Z. (2022), The journal of Biological chemistry. 298, 5, 101806

  • DAP5 drives translation of specific mRNA targets with upstream ORFs in human embryonic stem cells

    Authors: David M., Olender T., Mizrahi O., Weingarten-Gabbay S., Friedlander G., Meril S., Goldberg N., Savidor A., Levin Y., Salomon V., Stern-Ginossar N., Bialik S. & Kimchi A. (2022), RNA (Cambridge). 28, 10, p. 1325-1336

  • Macrophage-Secreted CSF1 Transmits a Calorie Restriction-Induced Self-Renewal Signal to Mammary Epithelial Stem Cells

    Authors: Kosenko A., Salame T. M., Friedlander G. & Barash I. (2022), Cells (Basel, Switzerland). 11, 18, 2923

  • TENT4A Non-Canonical Poly(A) Polymerase Regulates DNA-Damage Tolerance via Multiple Pathways That Are Mutated in Endometrial Cancer

    Authors: Swain U., Friedlander G., Sehrawat U., Sarusi-Portuguez A., Rotkopf R., Ebert C., Paz-Elizur T., Dikstein R., Carell T., Geacintov N. E. & Livneh Z. (2021), International Journal of Molecular Sciences. 22, 13, 6957

  • Downregulated luteolytic pathways in the transcriptome of early pregnancy bovine corpus luteum are mimicked by interferon-tau in vitro

    Authors: Basavaraja R., Drum J. N., Sapuleni J., Bibi L., Friedlander G., Kumar S., Sartori R. & Meidan R. (2021), BMC Genomics. 22, 1, 452

  • CD74 is a regulator of hematopoietic stem cell maintenance

    Authors: Becker-Herman S., Rozenberg M., Hillel-Karniel C., Gil-Yarom N., Kramer M., Barak A., Sever L., David K., Radomir L., Lewinsky H., Levi M., Friedlander G., Bucala R., Peled A. & Shachar I. (2021), PLoS Biology. 19, 3, 3001121

  • Generation of caudal-type serotonin neurons and hindbrain-fate organoids from hPSCs

    Authors: Valiulahi P., Vidyawan V., Puspita L., Oh Y., Juwono V. B., Sittipo P., Friedlander G., Yahalomi D., Sohn J. W., Lee Y. K., Yoon J. K. & Shim J. w. (2021), Stem Cell Reports. 16, 8, p. 1938-1952

  • Phylogeny and abiotic conditions shape the diel floral emission patterns of desert Brassicaceae species

    Authors: Cna'ani A., Dener E., Ben-Zeev E., Günther J., Köllner T. G., Tzin V. & Seifan M. (2021), Plant, Cell and Environment. 44, 8, p. 2656-2671

  • IRS1 phosphorylation underlies the non-stochastic probability of cancer cells to persist during EGFR inhibition therapy

    Authors: Jacob Berger A., Gigi E., Kupershmidt L., Meir Z., Gavert N., Zwang Y., Prior A., Gilad S., Harush U., Haviv I., Stemmer S. M., Blum G., Merquiol E., Mardamshina M., Kaminski Strauss S., Friedlander G., Bar J., Kamer I., Reizel Y., Geiger T., Pilpel Y., Levin Y., Tanay A., Barzel B., Reuveni H. & Straussman R. (2021), Nature Cancer. 2, 10, p. 1055-1070

  • Nanobodies Targeting Prostate-specific Membrane Antigen for the Imaging and Therapy of Prostate Cancer

    Authors: Rosenfeld L., Sananes A., Zur Y., Cohen S., Dhara K., Gelkop S., Ben Zeev E., Shahar A., Lobel L., Akabayov B., Arbely E. & Papo N. (2020), Journal of Medicinal Chemistry. 63, 14, p. 7601-7615

  • The mitochondrial carrier Citrin plays a role in regulating cellular energy during carcinogenesis

    Authors: Rabinovich S., Silberman A., Adler L., Agron S., Levin-Zaidman S., Bahat A., Porat Z., Ben-Zeev E., Geva I., Itkin M., Malitsky S., Buchaklian A., Helbling D., Dimmock D. & Erez A. (2020), Oncogene. 39, 1, p. 164-175

  • CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

    Authors: Fuzesi-Levi M. G., Fainer I., Enchev R. I., Ben-Nissan G., Levin Y., Kupervaser M., Friedlander G., Salame T. M., Nevo R., Peter M. & Sharon M. (2020), Cell Death and Differentiation. 27, 3, p. 984-998

  • Conserved interactions required for inhibition of the main protease of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

    Authors: Shitrit A., Zaidman D., Kalid O., Bloch I., Doron D., Yarnizky T., Buch I., Segev I., Ben-Zeev E., Segev E. & Kobiler O. (2020), Scientific Reports. 10, 1, 20808

  • SLAMF9 regulates pDC homeostasis and function in health and disease

    Authors: Sever L., Radomir L., Strim K., Weiner A., Shchottlender N., Lewinsky H., Barak A. F., Friedlander G., Ben-Dor S., Becker-Herman S. & Shachar I. (2019), Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16489-16496

  • The transcriptional profile of circulating myeloid derived suppressor cells correlates with tumor development and progression in mouse

    Authors: Nachmany I., Bogoch Y., Friedlander-Malik G., Amar O., Bondar E., Zohar N., Hantisteanu S., Fainaru O., Lubezky N., Klausner J. M. & Pencovich N. (2019), Genes and Immunity. 20, 7, p. 589-598

  • Transcriptome analysis highlights nuclear control of chloroplast development in the shoot apex

    Authors: Dalal V., Dagan S., Friedlander G., Aviv E., Bock R., Charuvi D., Reich Z. & Adam Z. (2018), Scientific Reports. 8, 1, 8881

  • Pre-equilibrium competitive library screening for tuning inhibitor association rate and specificity toward serine proteases

    Authors: Cohen I., Naftaly S., Ben-Zeev E., Hockla A., Radisky E. S. & Papo N. (2018), Biochemical Journal. 475, p. 1335-1352

  • Augmented expression of RUNX1 deregulates the global gene expression of U87 glioblastoma multiforme cells and inhibits tumor growth in mice

    Authors: Bogoch Y., Friedlander-Malik G., Lupu L., Bondar E., Zohar N., Langier S., Ram Z., Nachmany I., Klausner J. M. & Pencovich N. (2017), Tumor Biology. 39, 4

  • CD74 is a novel transcription regulator

    Authors: Gil-Yarom N., Radomir L., Sever L., Kramer M. P., Lewinsky H., Bornstein C., Blecher-Gonen R., Barnett Itzhaki Z., Mirkin V., Friedlander G., Shvidel L., Herishanu Y., Lolis E. J., Becker Herman S., Amit I. & Shachar I. (2017), Proceedings of the National Academy of Sciences of the United States of America. 114, 3, p. 562-567

  • Coordination of Meristem Doming and the Floral Transition by Late Termination, a Kelch Repeat Protein

    Authors: Tal L., Friedlander G., Gilboa N. S., Unger T., Gilad S. & Eshed Y. (2017), Plant Cell. 29, 4, p. 681-696

  • Seasonal heat stress affects adipose tissue proteome toward enrichment of the Nrf2-mediated oxidative stress response in late-pregnant dairy cows

    Authors: Zachut M., Kra G., Livshitz L., Portnick Y., Yakoby S., Friedlander G. & Levin Y. (2017), Journal of Proteomics. 158, p. 52-61

  • A computational combinatorial approach identifies a protein inhibitor of superoxide dismutase 1 misfolding, aggregation, and cytotoxicity

    Authors: Banerjee V., Oren O., Ben-Zeev E., Taube R., Engel S. & Papo N. (2017), Journal of Biological Chemistry. 292, 38, p. 15777-15788

  • The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel

    Authors: Wekselman I., Zimmerman E., Davidovich C., Belousoff M., Matzov D., Krupkin M., Rozenberg H., Bashan A., Friedlander G., Kjeldgaard J., Ingmer H., Lindahl L., Zengel J. M. & Yonath A. (2017), Structure. 25, 8, p. 1233-1241.e3

  • Proteome dataset of subcutaneous adipose tissue obtained from late pregnant dairy cows during summer heat stress and winter seasons

    Authors: Zachut M., Kra G., Livshitz L., Portnick Y., Yakoby S., Friedlander G. & Levin Y. (2017), Data in Brief. 12, p. 535-539

  • Using synthetic mouse spike-in transcripts to evaluate RNA-seq analysis tools

    Authors: Leshkowitz D., Feldmesser E., Friedlander G., Jona G., Ainbinder E., Parmet Y. & Horn-Saban S. (2016), PLoS ONE. 11, 4, e0153782

  • Prediction of homoprotein and heteroprotein complexes by protein docking and template-based modeling: A CASP-CAPRI experiment

    Authors: Lensink M. F., Velankar S., Kryshtafovych A., Huang S., Schneidman-Duhovny D., Sali A., Segura J., Fernandez-Fuentes N., Viswanath S., Elber R., Grudinin S., Popov P., Neveu E., Lee H., Baek M., Park S., Heo L., Lee G. R., Seok C., Qin S., Zhou H., Ritchie D. W., Maigret B., Devignes M., Ghoorah A., Torchala M., Chaleil R. A. G., Bates P. A., Ben-Zeev E., Eisenstein M., Negi S. S., Weng Z., Vreven T., Pierce B. G., Borrman T. M., Yu J., Ochsenbein F., Guerois R., Vangone A., Rodrigues J. P. G. L. M., van Zundert Z. G., Nellen M., Xue L., Karaca E., Melquiond A. S. J., Visscher K., Kastritis P. L., Bonvin A. M. J. J., Xu X., Qiu L., Yan C., Li J., Ma Z., Cheng J., Zou X., Shen Y., Peterson L. X., Kim H., Roy A., Han X., Esquivel-Rodriguez J., Kihara D., Yu X., Bruce N. J., Fuller J. C., Wade R. C., Anishchenko I., Kundrotas P. J., Vakser I. A., Imai K., Yamada K., Oda T., Nakamura T., Tomii K., Pallara C., Romero-Durana M., Jimenez-Garcia B., Moal I. H., Fernandez-Recio J., Joung J. Y., Kim J. Y., Joo K., Lee J., Kozakov D., Vajda S., Mottarella S., Hall D. R., Beglov D., Mamonov A., Xia B., Bohnuud T., Del Capiro C. C. A., Ichiishi E., Marze N., Kuroda D., Burman S. S. R., Gray J. J., Chermak E., Cavallo L., Oliva R., Tovchigrechko A. & Wodak S. J. (2016), Proteins-Structure Function And Bioinformatics. 84, p. 323-348

  • A metabolic gene cluster in the wheat W1 and the barley Cer-cqu loci determines β-diketone biosynthesis and glaucousness

    Authors: Hen Avivi A. S., Savin O., Racovita R. C., Lee W., Adamski N. M., Malitsky S., Almekias-Siegl E., Levy M., Vautrin S., Berges H., Friedlander G., Kartvelishvily E., Ben-Zvi G., Alkan N., Uauy C., Kanyuka K., Jetter R., Distelfeld A. & Aharoni A. (2016), Plant Cell. 28, 6, p. 1440-1460

  • A novel allosteric mechanism of NF-κB dimerization and DNA binding targeted by an anti-inflammatory drug

    Authors: Ashkenazi S., Plotnikov A., Bahat A., Ben-Zeev E., Warszawski S. & Dikstein R. (2016), Molecular and Cellular Biology. 36, 8, p. 1237-1247

  • Selective assembly of Na,K-ATPase α2 β2 Heterodimers in the Heart: Distinct functional properties and isoform-selective inhibitors

    Authors: Habeck M., Tokhtaeva E., Nadav Y., Ben-Zeev E., Ferris S., Kaufman R., Bab-Dinitz E., Kaplan J., Dada L., Farfel Z., Tal D., Katz A., Sachs G., Vagin O. & Karlish S. (2016), Journal of Biological Chemistry. 291, 44, p. 23159-23174

  • Digoxin derivatives with selectivity for the alpha 2 beta 3 isoform of Na,K-ATPase potently reduce intraocular pressure

    Authors: Heller D., Marcovich A., Katz A., Tal D. M., Habeck M., Ben-Zeev E., Rabah B., Barkana Y. & Karlish S. J. (2016),

  • Cap-independent translation by DAP5 controls cell fate decisions in human embryonic stem cells

    Authors: Kimchi A., Yoffe Y., David M., Kalaora R., Povodovski L., Friedlander G., Feldmesser E. & Ainbinder E. (2016), GENES & DEVELOPMENT. 30, 17, p. 1991-2004

  • Digoxin derivatives with selectivity for the α2β3 isoform of Na,K-ATPase potently reduce intraocular pressure

    Authors: Katz A., Tal D. M., Heller D., Habeck M., Ben-Zeev E., Rabah B., Bar Kana K. Y., Marcovich A. L. & Karlish S. J. (2015), Proceedings of the National Academy of Sciences of the United States of America. 112, 44, p. 13723-13728

  • Simultaneous transcriptome analysis of Colletotrichum gloeosporioides and tomato fruit pathosystem reveals novel fungal pathogenicity and fruit defense strategies

    Authors: Alkan N., Friedlander G., Ment D., Prusky D. & Fluhr R. (2015), NEW PHYTOLOGIST. 205, 2, p. 801-815

  • The Transcription and Translation Landscapes during Human Cytomegalovirus Infection Reveal Novel Host-Pathogen Interactions

    Authors: Tirosh O., Cohen Y., Shitrit A., Shani O., Le-Trilling V. T. K., Trilling M., Friedlander G., Tanenbaum M. & Stern-Ginossar N. (2015), PLoS Pathogens. 11, 11, e1005288

  • Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis

    Authors: Zigmond E., Bernshtein B., Friedlander G., Walker C. R., Yona S., Kim K., Brenner O., Krauthgamer R., Varol C., Mueller W. & Jung S. (2014), Immunity. 40, 5, p. 720-733

  • Strategy of transcription regulation in the budding yeast

    Authors: Levy S., Ihmels J., Carmi M., Weinberger A., Friedlander G. & Barkai N. (2014), Investigations in Yeast Functional Genomics and Molecular Biology. Eckwahl M. (eds.). p. 209-232

  • Divergent Levels of LBP and TGFβ1 in Murine MSCs Lead to Heterogenic Response to TLR and Proinflammatory Cytokine Activation

    Authors: Levin S., Pevsner-Fischer M., Kagan S., Lifshitz H., Weinstock A., Gataulin D., Friedlander G. & Zipori D. (2014), Stem Cell Reviews and Reports. 10, 3, p. 376-388

  • Global aspects of pacC regulation of pathogenicity genes in colletotrichum gloeosporioides as revealed by transcriptome analysis

    Authors: Alkan N., Meng X., Friedlander G., Reuveni E., Sukno S., Sherman A., Thon M., Fluhr R. & Prusky D. (2013), Molecular Plant-Microbe Interactions. 26, 11, p. 1345-1358

  • Runx3-mediated transcriptional program in cytotoxic lymphocytes

    Authors: Lotem J., Levanon D., Negreanu V., Leshkowitz D., Friedlander G. & Groner Y. (2013), PLoS ONE. 8, 11, e80467

  • Mutant p53 Attenuates the Anti-Tumorigenic Activity of Fibroblasts-Secreted Interferon Beta

    Authors: Madar S., Harel E., Goldstein I., Stein Y., Kogan-Sakin I., Kamer I., Solomon H., Dekel E., Tal P., Goldfinger N., Friedlander G. & Rotter V. (2013), PLoS ONE. 8, 4, e61353

  • A dynamic view of domain-motif interactions

    Authors: Akiva E., Friedlander G., Itzhaki Z. & Margalit H. (2012), PLoS Computational Biology. 8, 1, e1002341

  • Failure of the tomato trans-acting short interfering RNA program to regulate AUXIN response FACTOR3 and ARF4 underlies the wiry leaf syndrome

    Authors: Yifhar T., Pekker I., Peled D., Friedlander G., Pistunov A., Sabban M., Wachsman G., Alvarez J. P., Amsellem Z. & Eshed Y. (2012), Plant Cell. 24, 9, p. 3575-3589

  • Ly6Chi Monocytes in the Inflamed Colon Give Rise to Proinflammatory Effector Cells and Migratory Antigen-Presenting Cells

    Authors: Zigmond E., Varol C., Farache J., Elmaliah E., Satpathy A. T., Friedlander G., Mack M., Shpigel N., Boneca I. G., Murphy K. M., Shakhar G., Halpern Z. & Jung S. (2012), Immunity. 37, 6, p. 1076-1090