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The The Maurice and Vivienne Wohl Institute for Drug Discovery unit offers a collection of industry-standard instruments to enable miniaturization and automation of most biological assay systems.

Many of these devices can be operated in stand-alone or in integrated automation platforms to allow runs of several plates to hundreds of plates.

 

HTS 1 (large scale screening system)

This system includes:

  • Thermo Spinnaker Robot
  • BMG Pherastar FS plate reader
  • Molecular Devices Velos scanning cytometer
  • Agilent Bravo liquid handler
  • Biotek EL406 plate washer
  • BNX 1536 plate washer
  • Thermo Combi dispenser (2 units)
  • Thermo C10 hotel (250 plate ambient storage)
  • Liconic STX 220 (220 plate incubation)
  • Bluecatbio Blue washer

HTS 2 (small scale proliferation assays)

This System includes:

  • CyBi robot arm
  • Biotek EL406 plate washer
  • Ambient plate storage
  • Liconic STX 44 (44 plate incubation

HCS (automated microscopy and imaging)

This system includes:

  • HiRes Acell robot arm
  • Molecular Devices ImagExpress confocal microscop
  • TTPlabtech Acumen scanning cytometer
  • Liconic STX 44 (44 plate incubation)

CM 1 (assay plate preparation)

This system includes:

  • Labcyte Access robot arm
  • Labcyte Echo 555 acoustic liquid handler; 2 units
  • Thermo Cytomat C10  (250 plates incubator)
  • Thermo Cytomat 6002  (250 plates dry storage)
  • Agilent Vspin plate centrifuge
  • Agilent Plateloc plate sealer
  • Brooks Xpeel plate peeler

CM 2 (library plate management)

This system includes:

  • HiRes Acell robot arm
  • Agilent Bravo liquid handler
  • HiRes centrifuge
  • Agilent Plateloc plate sealer
  • Agilent Vcode barcode printer
  • HiRes nanoserve (labware storage)
  • HiRes picoserve (48 plate storage)

XL 100 (compound dissolving and vial management)

This system includes:

  • Biomicrolab balance
  • Biomicrolab vial-handling gripper
  • Tecan single channel liquid handler

Stand-alone instruments

The instruments are

  • Pherastar FS Offline (plate reader)
  • GNF WDII (Plate washer and dispenser)
  • Nanotemper Monolith (microscale thermophoresis for target engagement)
  • Nanotemper NT Label-free (microscale thermophoresis for target engagement)
  • Thermo Combi dispenser