de Botton Institute for Protein Profiling


  1. N Mor, Y Rais, S Peles, D Sheban,.., Dalia Elinger, .., Yishai Levin, R Massarwa, Y Merbl, .., Jacob H. Hanna.  “Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naïve Pluripotency”. Cell Stem Cell, 2018.
  2. H W Levy,..,D Morgenstern,.. A Savidor,..,Y Levin, Yifat Merbl. “Defining the cellular proteolytic landscape by proteasomal profiling”. Nat. Biotech. Accepted.
  3. A SavidorR BarzilayD ElingerY YardenM LindzenA GabashviliO Adiv Tal and Yishai Levin, "Database Independent Protein Sequencing (DiPS) enables full-length de-novo protein and antibody sequence determination", MCP 2017.
  4. Z Erez, I S Levy, M Shamir, S Doron, A S Avihail, Y Peleg, S Melamed, A Leavitt, A Savidor, S Albeck, G Amitai and R Sorek, "Communication between viruses guides lysis–lysogeny decisions", Nature 2017.
  5. Levy M, Thaiss CA, Zeevi D, Dohnalová L, Zilberman-Schapira G, Mahdi JA, David E, Savidor A, Korem T, Herzig Y, Pevsner-Fischer M, Shapiro H, Christ A, Harmelin A, Halpern Z, Latz E, Flavell RA8, Amit I, Segal E, Elinav E. "Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling", Cell 2015.
  6. S Rozen, M G Fuzesi-Levi, G Ben-Nissan, L Mizrachi, A Gabashvili, Y Levin, M Sharon. "CSNAP Is a Stoichiometric Subunit of the COP9 Signalosome". Cell Reports, 2015
  7. U Alcolombri, S Ben-Dor, E Feldmesser, Y Levin, D S. Tawfik and A Vardi. "Identification of the algal dimethyl sulfide releasing enzyme - a missing link in the marine sulfur cycle". Science2015.

Other publications

  1. N Myers,  T Olender,  A SavidorY Levin,  Nina Reuven  Yosef Shaul. “The Disordered Landscape of the 20S Proteasome Substrates Reveals Tight Association with Phase Separated Granules”, Proteomics 2018.

  2. N Edison, Curtz Y,..., Morgenstern D, Kupervaser M,.., Larisch S, Degradation of Bcl-2 by XIAP and ARTS Promotes Apoptosis", Cell Reports 2017.
  3. D Despotovic, .., A Savidor, Y Levin and D Tawfik"Diadenosine tetraphosphate (Ap4A) – an E. coli alarmone or a damage metabolite?". Accepted FEBS.
  4. M Zachut, G Kra, L Livshitz, Y Portnick, S Yakoby, G Friedlander and Y Levin, "Seasonal heat stress affects adipose tissue proteome toward enrichment of the Nrf2-mediated oxidative stress response in late-pregnant dairy cows", J of Proteomics 2017.
  5. G Armony, E Jacob, T Moran, Y Levin, T Mehlman, Y Levy, D Fass, "Cross-linking reveals laminin coiled-coil architecture", PNAS 2016.
  6. I Solomonov, E Zehorai, D T Frank, A Shainskaya, A Zuravlev, E Kartvelishvily, R Visse, Y Levin, N Kampf, D Jaitin, E David, I Amit, K Nagase, I Sagi. "Distinct biological events generated by ECM proteolysis by two homologous collagenases", PNAS 2016.
  7. S Graff, S Rosenwasser, Y Levin, A Vardi. "Chronic iron limitation confers transient resistance to oxidative stress in marine diatoms". Plant Physiology 2016.
  8. M Zachut, P Sood, Y Levin, U Moallem. "Proteomic analysis of preovulatory follicular fluid reveals differentially abundant proteins in less fertile dairy cows". J Proteomics 2016.
  9. N Borovok, E Nesher, Y Levin, M Reichenstein, A Pinchasov, I Michaelevsky, "Dynamics of Hippocampal Protein Expression During Long-term Spatial Memory Formation", Molecular Cellular Proteomics 2016.
  10. T ShalitD ElingerA SavidorA Gabashvili and Y Levin. "MS1-based label-free proteomics using a quadrupole orbitrap mass spectrometer", J Prot Res, 2015.
  11. H Zigdon, A SavidorY Levin, A Meshcheriakova, R Schiffmann and A H Futerman. "Indentification of a biomarker in cerebrospinal fluid for neuronopathic forms of Gaucher disease". PLoS One, 2015.
  12. N Borovok, E Nesher, Y Levin, M Reichenstein, A Pinhasov and Izhak Michaelevski. "Dynamics of hippocampal protein expression during long-term spatial memory formation". Molecular Cellular Proteomics, 2015
  13. T Bucher, Y Oppenheimer-Shaanan, A Savidor, Z Bloom-Ackermann and I Kolokdin-Gal. "Disturbance of the bacterial cell wall specifically interferes with biofilm formation". Environmental Microbiology Reports 2015.
  14. E Nesher, I Koman, M Gross, T Tikhonov, M Bairachnaya, M Salmon-Divon, Y levin, I Michaelevsky, G Yadid and A Pinhasov. "Synapsin IIb as a function marker of submissive behavior". Sceintific Reports 2015.
  15. G Zipor, P Duarte, I Carqueijeiro, L Shahar, R Ovadia, P T Bamnolker, D Eshel, Y Levin, A D Faigenboim, M Sottomayor, M O Shamir. "In planta anthocyanin degradation by a vacuolar calss III peroxidase in Brunfelsia calycina flowers". New Phytologist 2015.
  16. L Davidi, Y Levin, S Ben-Dor, U Pick. "Proteome analysis of cytoplasmic and of plasticid beta-carotene lipid droplets in Dunaliella bardawil". Plant Physiology 2015.
  17. U Distler, J Kuharev, P Navarro, Y Levin, H Schild and S Tenzer. 'Drift-specific collision energies enable deep coverage data-independent acquisition proteomics'. Nature Methods, 2014.
  18. M Fraiberg, A Oshri, C Cassidy, A Gabashvili, K Schulten, Y Levin, M Eisenbach. "CheY’s acetylation sites responsible for generating clockwise flagellar rotation in Escherichia coli". Moleculer Microbiology 2014.
  19. Book chapterY Levin. "Label-free quantification using data independent acquisition”. Book tittle: Quantitative Proteomics: Techniques and Applications. RSC 2014.
  20. Book chapter: A Savidor, Y Levin."Quantification of proteins using label-free LC-MSE". Book tittle: Method in Molecular Biology, Springer 2014.
  21. M G Fuzesi-Levi, G Ben-Nissan, E Bianchi, H Zhou, M J Deery, K S Lilley, Y Levin, M Sharon. “Dynamic regulation of the COP9 signalosome in response to DNA damage”. Mol. Cell. Biology 2014.
  22. S Rosenwasser, S Gvan Creveld, D Schatz, S Malitsky, O Tzfadia, A Aharoni, Y Levin et al. “Mapping the diatom redox-sensitive proteome provides insights into response to nitrogen stress in the marine environment”. PNAS 2014.
  23. N L yona, Y Levin, K C Dannemiller, O Yarden, J Peccia, Y Roduch. 'Changes in atmospheric CO2 influence the allergenicity of Aspergillus fumigatus. Glob. Change Biology 2013.
  24. V Stelzhammer, B Amess, DM de-Souza, Y Levin, S Ozanne, M Martin-Gronert, S Urday, S Bahn, P. C. Guest. 'Analysis of the rat hypothalamus proteome by data-independent label-free LC-MS/MS'. Proteomics 2012.
  25. K Thalassinos, J PC Vissers, S Tenzer, Y Levin, J W Thompson, D Daniel, D Mann, M R DeLong, M A Moseley, A H America, A K Ottens, G S Cavey, G Efstathiou, J H Scrivens, J I Langridge, S J Geromanos. 'Design and Application of a Data Independent Precursor and Product Ion Repository'. J Am Soc Mass Spec 2012.
  26. M F. Morgenstern, V Lacroix, I Ezkurdia, Y Levin, A Gabashvili, J Prilusky, A del Pozo, M Tress, R Johnson, R Guigo and A Valencia. 'Chimeras taking shape: Potential functions of proteins encoded by chimeric RNA transcripts'. Genome Research 2012. (PMID: 22588898).

* These authors contributed equally.


Small secreted proteins enable biofilm development in the cyanobacterium Synechococcus elongatus, Rakefet Schwarz.

Regulatory module involving FGF13, miR-504, and p53 regulates ribosomal biogenesis and supports cancer cell survival, Moshe Oren.