Medicinal Chemistry

UPLC MS: WATERS Acquity H Class UPLC with SQD2, PDA, and ELSD detectors

Improve your laboratory’s efficiency by scaling your methods to UPLC Technology
Use UPLC’s unmatched resolution to get better characterization of your complex samples
Take advantage of tools that simplify and streamline your method development workflow
Future-proof your lab by running your existing HPLC and UHPLC methods today and then transitioning to UPLC when you are ready

 

Features and Benefits

Get the flexibility of multi-solvent blending with the Quaternary Solvent Manager (QSM), and blend four solvents in any combination or proportion. Expand to up to nine solvents with the optional and integrated solvent-select valve for even greater flexibility. Automated solvent compressibility allows you to run any solvent in any combination without loss in accuracy or precision.
High-precision injections with direct inject sampling. The needle-in-flow path design ensures an accurate needle seal at high pressure. Injection volumes from 0.1 µL up to 1 mL are supported. Ultra-low carryover is managed through programmable method settings to ensure compatibility even with the most sensitive mass spectrometers.
Accurate temperature control across the entire column. Configurable for 1 to 6 columns, each housed in individual temperature controlled zones with active pre-heating and a temperature range of 4 to 90 °C.
Low-dispersion detection capabilities. The ACQUITY UPLC H-Class System is the only quaternary LC system in the market with a wide range of detectors that have been optimized for true UPLC performance. Minimizing dispersion and optimizing the electronics and optical paths for the narrow UPLC peaks yields the highest sensitivity and repeatability with the most accurate quantification.
Significantly reduce the time you spend in the prep lab by automating the formulation of mobile phases at specific pH and ionic strength from reservoirs of pure solvents or concentrated stock solutions using Auto•Blend Plus Technology. Compatible with reversed phase, IEX, and SEC, this technology makes routine analyses easier to manage and execute and streamlines method development and method robustness testing by allowing you to test even the smallest changes in pH and ionic strength without needing to make each individual buffer. 
Automatically manage gradient start time and pre-injection steps in parallel with SmartStart Technology. This allows you to compensate for system volume differences when transferring methods between different LC systems or to minimize inject-to-inject cycle times for high throughput applications.
Compliance ready. Qualification of laboratory instrumentation is an integral part of compliance with regulatory and quality standards such as GMP, GLP, ISO 17025, USP <1058>, and others. The ACQUITY UPLC H-Class System supports Waters Empower based automated system qualification tool (SQT), which minimizes the time and cost associated with annual qualification. 
Supported in Empower, Masslynx, UNIFI, and several 3rd party software packages.