Medicinal Chemistry

Chemical Libraries

Supplier

Library Name

Library Size

Characteristics

Analyticon

MEGxp: Pure natural compounds from plants

436

2014 collection – pure Natural Products MEGx, isolated from plants or microorganism, that are currently available in > 10 mg, purity > 85%

Analyticon

MEGxm: Pure natural compounds from microorganisms

469

2014 collection – pure Natural Products MEGx, isolated from plants or microorganism, that are currently available in > 10 mg, purity > 85%

Analyticon

MEGxp: Pure natural compounds from plants

3540

2012 collection – A collection of highly purified plant metabolites that is enriched in bioactivity

ChemBridge

DIVERSet™-CL

50000

Drug-like compounds represented in the DIVERSet™ libraries are carefully selected to provide the broadest pharmacophore space coverage possible within a 50,000 compound set of diverse structures.

Enamine

Drug-Like Set (DLS)

20160

Drug-like compounds selected using diversity sorting from the combined file of HTS and Historical collections. All compounds within the set strictly conform to rules of Lipinski and Veber, and do not bear undesired reactive functional groups.

EU OpenScreen Pilot Collection

Small molecules restricted access

~2000

Please contact Dr. Haim Barr, head of HTS platform

LOPAC/SIGMA

Navigator LOPAC1280

1280

Library of Pharmacologically Active Compounds

MayBridge

HitFinderTM Collection

14400

The HitFinderTM Collection consists of 14,400 MayBridge Screening Compounds, selected to represent the diversity of the MayBridge Screening Collection using a clustering algorithm based on standard Daylight Fingerprints and Tanimoto similarity

MicroSource

Spectrum Collection-Known Drugs (66%),  Natural Products (26%) and Other Bioactive Components (8%)

2400

The Spectrum Collection

Prestwick

Bioactive peptides

160

The Prestwick Peptide Library consists of 160 well-characterized, high purity-peptides. It is ideally suited to characterize orphan receptors by means of reverse pharmacology approaches, to validate new HTS assays or to help define relevant screening strategies

Prestwick

Prestwick Chemical Library® – approved drugs

1200

100% approved drugs (FDA, EMEA and other agencies)

Prestwick

PYR – restricted access

~1500

Please contact Dr. Haim Barr, head of HTS platform

WIS collection

Secreted proteins

~300

Please contact Dr. Haim Barr, head of HTS platform

Selleck Chemicals

Natural Product Library

144

A unique collection of 144 natural products for high throughput screening (HTS) and high content screening (HCS)

Structurally diverse, bioactive, and cell permeable

Selleck Chemicals

Bioactive Screening Libraries

1681

A unique collection of 1681 bioactive chemical compounds for high throughput screening (HTS) and high content screening (HCS)

Bioactivity and safety confirmed by preclinical research and clinical trials

Some compounds have been approved by the FDA

Includes most Selleck inhibitors, APIs, natural products, and chemotherapeutic agents

Structurally diverse, medicinally active, and cell permeable

GSK

GSK Published Kinase Inhibitor Set (PKIS)

367

The set has been widely distributed to academic collaborators as an open access tool. It has been used to identify chemical starting points for development of chemical probes for orphan kinases and to investigate kinase signalling in high content phenotypic assays. Authorization required from GSK.

Singapore Bioimaging Consortium/National University of Singapore

Diversity Oriented Fluorescence Library

~ 8000

Please contact Dr. Haim Barr, head of HTS platform